GSTT2
glutathione S-transferase theta 2 (gene/pseudogene)
Summary
The protein encoded by this gene, glutathione S-transferase (GST) theta 2 (GSTT2), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT2 and GSTT2B are nearly identical to each other, and share 55% amino acid identity with GSTT1. All three genes may play a role in human carcinogenesis. The GSTT2 gene is a pseudogene in some populations. [provided by RefSeq, Sep 2015]
Known Variants7 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs751153388 | 22:24,300,751 | G/A | — | uncertain significance |
| rs2517355684 | 22:24,300,758 | C/T | — | uncertain significance |
| rs761523379 | 22:24,300,763 | G/A | — | uncertain significance |
| rs1370190810 | 22:24,300,808 | C/T | — | uncertain significance |
| rs181983734 | 22:24,302,480 | C/T | — | likely pathogenic |
| rs2517358319 | 22:24,302,496 | A/G | — | uncertain significance |
| rs146675046 | 22:24,325,149 | G/A | missense variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.