GTSE1
G2 and S-phase expressed 1
Summary
The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis. [provided by RefSeq, Jul 2008]
Known Variants69 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs764158562 | 22:46,693,316 | C/T | — | uncertain significance |
| rs371733494 | 22:46,693,331 | G/A | — | uncertain significance |
| rs201036893 | 22:46,693,337 | C/G | — | benign |
| rs1465030794 | 22:46,693,355 | A/G | — | uncertain significance |
| rs1417004990 | 22:46,693,364 | C/G | — | uncertain significance |
| rs145763800 | 22:46,694,050 | G/A | downstream gene variant | — |
| rs116137618 | 22:46,704,039 | C/T | — | benign |
| rs760434191 | 22:46,704,367 | A/G | — | uncertain significance |
| rs202151215 | 22:46,704,399 | A/C | — | uncertain significance |
| rs201086044 | 22:46,704,401 | T/C | — | uncertain significance |
| rs2518775445 | 22:46,704,418 | A/G | — | uncertain significance |
| rs1190245568 | 22:46,704,426 | C/G | — | uncertain significance |
| rs372738082 | 22:46,704,428 | G/A | — | uncertain significance |
| rs2518775650 | 22:46,704,541 | A/G | — | uncertain significance |
| rs34660725 | 22:46,704,555 | G/A | — | benign |
| rs753807788 | 22:46,704,572 | C/T | — | uncertain significance |
| rs34725504 | 22:46,704,580 | C/T | — | benign |
| rs35141277 | 22:46,704,610 | G/T | — | benign |
| rs375036882 | 22:46,704,617 | A/T | — | uncertain significance |
| rs149905369 | 22:46,704,627 | C/G | — | likely benign |
| rs772107261 | 22:46,704,641 | C/T | — | uncertain significance |
| rs1219180435 | 22:46,704,661 | G/T | — | uncertain significance |
| rs752322552 | 22:46,704,683 | C/T | — | uncertain significance |
| rs2518776018 | 22:46,704,721 | G/C | — | uncertain significance |
| rs34404175 | 22:46,704,734 | C/T | — | benign |
| rs563937975 | 22:46,704,812 | G/A | — | uncertain significance |
| rs2147818030 | 22:46,704,817 | A/T | — | uncertain significance |
| rs554076001 | 22:46,708,141 | A/G | — | likely benign |
| rs375573110 | 22:46,708,147 | C/T | — | uncertain significance |
| rs35503220 | 22:46,708,152 | G/A | — | benign |
| rs201701933 | 22:46,708,156 | G/A | — | likely benign |
| rs1173395963 | 22:46,709,829 | A/G | — | likely benign |
| rs768420011 | 22:46,711,971 | G/A | — | uncertain significance |
| rs780711134 | 22:46,711,976 | C/G | — | uncertain significance |
| rs142788611 | 22:46,712,019 | T/C | — | likely benign |
| rs147408487 | 22:46,712,021 | C/T | — | likely benign |
| rs372072364 | 22:46,712,109 | C/T | — | likely benign |
| rs573781773 | 22:46,712,110 | G/A | — | likely benign |
| rs145136754 | 22:46,712,138 | C/T | — | uncertain significance |
| rs2518782998 | 22:46,712,208 | A/G | — | uncertain significance |
| rs2077780648 | 22:46,712,255 | A/T | — | uncertain significance |
| rs371308995 | 22:46,712,261 | G/C | — | uncertain significance |
| rs1158686961 | 22:46,712,277 | C/A | — | uncertain significance |
| rs759516336 | 22:46,712,285 | T/C | — | uncertain significance |
| rs775422568 | 22:46,712,295 | C/T | — | uncertain significance |
| rs201709046 | 22:46,719,132 | G/T | — | uncertain significance |
| rs377343356 | 22:46,719,135 | C/T | — | likely benign |
| rs768082145 | 22:46,719,144 | G/A | — | uncertain significance |
| rs376361349 | 22:46,722,340 | G/T | — | uncertain significance |
| rs201815677 | 22:46,722,361 | C/A | — | uncertain significance |
| rs77719017 | 22:46,722,397 | G/A | — | benign |
| rs1393426138 | 22:46,722,418 | C/T | — | uncertain significance |
| rs765339862 | 22:46,722,433 | C/T | — | uncertain significance |
| rs747805494 | 22:46,722,434 | G/A | — | uncertain significance |
| rs148210496 | 22:46,722,436 | C/T | — | uncertain significance |
| rs201142261 | 22:46,722,511 | C/T | — | uncertain significance |
| rs201762133 | 22:46,722,512 | G/A | — | uncertain significance |
| rs773718624 | 22:46,722,547 | A/G | — | likely benign |
| rs769744804 | 22:46,724,595 | A/G | — | likely benign |
| rs150583872 | 22:46,724,641 | C/T | — | uncertain significance |
| rs1251996584 | 22:46,724,658 | C/G | — | uncertain significance |
| rs745878303 | 22:46,724,665 | C/T | — | uncertain significance |
| rs772946279 | 22:46,724,700 | G/A | — | likely benign |
| rs1375063707 | 22:46,724,755 | C/G | — | uncertain significance |
| rs16995138 | 22:46,725,288 | G/A | — | benign |
| rs2518108035 | 22:46,725,300 | G/A | — | uncertain significance |
| rs368413568 | 22:46,725,456 | G/T | — | uncertain significance |
| rs1025100817 | 22:46,725,463 | A/G | — | uncertain significance |
| rs531671052 | 22:46,726,001 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.