GUCY1A2
guanylate cyclase 1 soluble subunit alpha 2
Summary
Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Known Variants30 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1390362284 | 11:106,558,444 | C/T | — | uncertain significance |
| rs1202007346 | 11:106,558,471 | C/A | — | uncertain significance |
| rs764594827 | 11:106,579,269 | G/C | — | uncertain significance |
| rs2496449959 | 11:106,579,334 | G/A | — | uncertain significance |
| rs781424682 | 11:106,647,172 | G/T | — | uncertain significance |
| rs267602682 | 11:106,647,209 | C/G | — | uncertain significance |
| rs2496618842 | 11:106,680,978 | C/G | — | uncertain significance |
| rs577353618 | 11:106,691,239 | C/T | — | — |
| rs117646729 | 11:106,810,558 | A/G | — | benign |
| rs753774502 | 11:106,810,605 | G/A | — | uncertain significance |
| rs758755207 | 11:106,810,617 | T/C | — | uncertain significance |
| rs2496464552 | 11:106,810,650 | A/G | — | uncertain significance |
| rs2508817882 | 11:106,810,725 | G/A | — | uncertain significance |
| rs1383672865 | 11:106,810,737 | T/C | — | uncertain significance |
| rs764427823 | 11:106,810,788 | C/T | — | uncertain significance |
| rs757595379 | 11:106,810,836 | C/T | — | uncertain significance |
| rs721625 | 11:106,819,557 | A/G | intron variant | — |
| rs2496532256 | 11:106,849,383 | T/G | — | uncertain significance |
| rs35760785 | 11:106,849,400 | G/C | — | uncertain significance |
| rs1357588205 | 11:106,849,465 | A/G | — | uncertain significance |
| rs188450102 | 11:106,856,804 | T/A | — | uncertain significance |
| rs200383697 | 11:106,856,842 | G/C | — | uncertain significance |
| rs768825523 | 11:106,856,850 | G/A | — | uncertain significance |
| rs771355218 | 11:106,888,531 | C/T | — | uncertain significance |
| rs575158116 | 11:106,888,583 | C/A | — | uncertain significance |
| rs746261199 | 11:106,888,622 | C/T | — | uncertain significance |
| rs772392728 | 11:106,888,633 | G/A | — | uncertain significance |
| rs1458290338 | 11:106,888,724 | C/T | — | uncertain significance |
| rs750619412 | 11:106,888,739 | C/T | — | uncertain significance |
| rs770545095 | 11:106,888,762 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.