H2AC8
H2A clustered histone 8
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
Known Variants5 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs181183660 | 6:26,215,308 | A/G | regulatory region variant | — |
| rs1051365311 | 6:26,215,416 | T/A | — | — |
| rs2480803060 | 6:26,217,293 | G/A | — | uncertain significance |
| rs961328184 | 6:26,217,318 | A/G | — | uncertain significance |
| rs2480803260 | 6:26,217,371 | G/C | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.