HAT1
histone acetyltransferase 1
Summary
The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jun 2009]
Known Variants12 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2165934 | 2:172,812,339 | G/A | intron variant | — |
| rs1305322223 | 2:172,821,932 | C/T | — | uncertain significance |
| rs2545394679 | 2:172,821,999 | T/G | — | uncertain significance |
| rs542631457 | 2:172,822,032 | A/G | — | uncertain significance |
| rs747359397 | 2:172,822,342 | A/G | — | uncertain significance |
| rs367808768 | 2:172,841,113 | A/T | — | uncertain significance |
| rs113528211 | 2:172,842,478 | A/T | — | — |
| rs72890842 | 2:172,843,278 | T/G | intron variant | — |
| rs759221623 | 2:172,844,236 | A/G | — | uncertain significance |
| rs369406305 | 2:172,844,247 | A/G | — | uncertain significance |
| rs1425955687 | 2:172,848,208 | G/C | — | uncertain significance |
| rs775715888 | 2:172,848,237 | C/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.