HBZ
hemoglobin subunit zeta
Summary
Zeta-globin is an alpha-like hemoglobin. The zeta-globin polypeptide is synthesized in the yolk sac of the early embryo, while alpha-globin is produced throughout fetal and adult life. The zeta-globin gene is a member of the human alpha-globin gene cluster that includes five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 -alpha-1 - theta1 - 3'. [provided by RefSeq, Nov 2009]
Known Variants7 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs544061540 | 16:201,599 | A/G | — | — |
| rs756903350 | 16:202,967 | C/T | — | uncertain significance |
| rs2858919 | 16:203,135 | T/G | — | — |
| rs2505406337 | 16:203,994 | G/A | — | uncertain significance |
| rs1303996959 | 16:204,028 | G/A | — | uncertain significance |
| rs531302321 | 16:204,126 | A/G | regulatory region variant | — |
| rs780341332 | 16:204,279 | C/T | — | likely benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.