HDAC2
histone deacetylase 2
Summary
This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
Known Variants24 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs11391 | 6:114,262,015 | A/C | 3 prime UTR variant | — |
| rs1159764466 | 6:114,262,927 | C/T | — | uncertain significance |
| rs373953184 | 6:114,264,546 | T/G | — | uncertain significance |
| rs1297073429 | 6:114,264,626 | C/T | — | uncertain significance |
| rs1252367140 | 6:114,265,437 | A/G | — | likely benign |
| rs1261159949 | 6:114,265,494 | T/C | — | uncertain significance |
| rs13204445 | 6:114,265,587 | T/A | — | — |
| rs77438668 | 6:114,267,287 | T/A | — | benign |
| rs1582482024 | 6:114,270,155 | G/A | — | likely benign |
| rs2482600581 | 6:114,270,364 | C/A | — | uncertain significance |
| rs6568819 | 6:114,270,928 | C/A | — | — |
| rs10499080 | 6:114,273,646 | C/T | intron variant | — |
| rs2482611700 | 6:114,274,523 | T/G | — | uncertain significance |
| rs1312623763 | 6:114,277,169 | T/G | — | likely benign |
| rs367736850 | 6:114,277,324 | T/C | — | likely benign |
| rs2475631 | 6:114,277,625 | T/C | intron variant | — |
| rs1776561501 | 6:114,277,818 | A/G | — | uncertain significance |
| rs1776561731 | 6:114,277,851 | A/G | — | uncertain significance |
| rs200805519 | 6:114,277,866 | G/T | — | benign |
| rs762681676 | 6:114,279,924 | G/A | — | uncertain significance |
| rs1554198179 | 6:114,281,142 | C/T | — | uncertain significance |
| rs114260386 | 6:114,281,189 | T/C | — | benign |
| rs2499618 | 6:114,285,253 | C/T | intron variant | — |
| rs547441777 | 6:114,290,646 | T/C | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.