HDAC5

histone deacetylase 5

Summary

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Known Variants79 total

rsidPosition (GRCh37)AllelesClassClinVar
rs77487011217:42,155,751G/A—uncertain significance
rs250938655117:42,155,773C/T—uncertain significance
rs37342757917:42,155,781G/A—uncertain significance
rs76350078517:42,155,874C/T—uncertain significance
rs13800526217:42,155,892G/A—benign
rs77250690417:42,155,911C/T—uncertain significance
rs74707464117:42,155,914C/T—uncertain significance
rs14908249417:42,155,989G/A—uncertain significance
rs37684796317:42,156,004C/T—uncertain significance
rs18902971417:42,156,042G/A—benign
rs250939081917:42,156,217G/C—uncertain significance
rs250939348717:42,156,541C/T—uncertain significance
rs250940057917:42,157,581C/A—uncertain significance
rs78045231817:42,157,809C/A—uncertain significance
rs13931210917:42,158,204G/T—benign
rs37399286617:42,158,205G/A—uncertain significance
rs806442817:42,158,253A/G—benign
rs37115412417:42,159,985A/T—uncertain significance
rs250942192517:42,160,920T/C—uncertain significance
rs103936064617:42,160,979A/C—uncertain significance
rs37469020517:42,160,981T/C—uncertain significance
rs250942235817:42,160,989T/C—uncertain significance
rs14252994417:42,161,005C/T—uncertain significance
rs37218077517:42,161,205T/G—uncertain significance
rs123738201417:42,161,934T/C—uncertain significance
rs103633513717:42,161,986G/A—uncertain significance
rs90434961417:42,162,485T/C—uncertain significance
rs37371396517:42,162,516G/C—likely benign
rs37597465317:42,163,984A/C—uncertain significance
rs20155367417:42,163,994G/A—uncertain significance
rs20075167017:42,164,059G/A—uncertain significance
rs75269872017:42,164,800G/C—uncertain significance
rs138974101917:42,164,870C/T—likely benign
rs205072615117:42,164,875C/T—uncertain significance
rs22875717:42,164,885G/C—benign
rs14823416017:42,164,894G/C—likely benign
rs14810642917:42,164,946C/T—uncertain significance
rs3391656017:42,164,970C/G—benign
rs14011992717:42,165,766G/T—uncertain significance
rs250945508117:42,165,813T/G—uncertain significance
rs145214617217:42,165,865G/T—uncertain significance
rs121120073217:42,165,897T/C—uncertain significance
rs78164674617:42,165,906G/A—uncertain significance
rs6175465117:42,165,918G/A—uncertain significance
rs14385104517:42,165,927C/T—uncertain significance
rs14639029317:42,165,928G/A—uncertain significance
rs250945587017:42,165,933C/T—uncertain significance
rs250945610517:42,165,960A/G—uncertain significance
rs77351216117:42,168,667T/C—uncertain significance
rs205093843117:42,168,707C/T—uncertain significance
rs133486092817:42,168,806G/C—uncertain significance
rs18837867617:42,168,830C/T—uncertain significance
rs6174646417:42,168,859G/T—uncertain significance
rs142620676117:42,169,093A/G—uncertain significance
rs173120421717:42,169,574C/A—uncertain significance
rs57808782817:42,169,632C/T—uncertain significance
rs54548660517:42,169,644C/T—uncertain significance
rs14089530617:42,169,758C/T—uncertain significance
rs77429560717:42,169,761C/T—uncertain significance
rs15039414917:42,169,817C/T—uncertain significance
rs75771273217:42,169,821G/A—uncertain significance
rs205101859317:42,170,106G/C—uncertain significance
rs11601781517:42,170,580G/A—benign
rs19999713017:42,170,692C/T—likely benign
rs76868180217:42,170,723T/C—uncertain significance
rs75494748617:42,170,756C/T—uncertain significance
rs74621152317:42,170,774C/T—uncertain significance
rs13890038817:42,170,825T/C—uncertain significance
rs11479615917:42,171,051C/T—benign
rs54093035017:42,171,107C/T—uncertain significance
rs37484491617:42,171,112G/A—likely benign
rs77192581717:42,171,207G/A—likely benign
rs17063417:42,175,821C/Aregulatory region variant—
rs17063717:42,186,868C/Tintron variant—
rs7785080817:42,186,950G/Aintron variant—
rs77872111617:42,188,112T/C—likely benign
rs22876917:42,193,185G/Cregulatory region variant—
rs205262727117:42,193,426C/A—uncertain significance
rs11211476417:42,201,041G/Tregulatory region variant—

Gene information from NCBI Gene. Variant classifications from ClinVar.