HDAC9
histone deacetylase 9
Summary
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined. [provided by RefSeq, Jul 2008]
Known Variants89 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1919314 | 7:18,140,361 | A/T | intron variant | — |
| rs1178365 | 7:18,177,404 | C/A | intron variant | — |
| rs13247375 | 7:18,183,650 | C/T | intron variant | — |
| rs6976429 | 7:18,196,417 | G/T | intron variant | — |
| rs1019068 | 7:18,200,463 | A/C | intron variant | — |
| rs13243921 | 7:18,204,018 | T/A | — | — |
| rs145741389 | 7:18,211,117 | T/A | intron variant | — |
| rs1406360 | 7:18,224,272 | A/T | — | — |
| rs1178323 | 7:18,237,168 | G/C | intron variant | — |
| rs34461394 | 7:18,240,151 | T/A | intron variant | — |
| rs302177 | 7:18,311,060 | G/C | intron variant | — |
| rs55744175 | 7:18,332,396 | G/C | — | — |
| rs185912594 | 7:18,355,933 | A/G | intron variant | — |
| rs17139048 | 7:18,370,718 | A/G | intron variant | — |
| rs12666612 | 7:18,375,245 | T/C | intron variant | — |
| rs12155400 | 7:18,428,921 | A/G | intron variant | — |
| rs551625260 | 7:18,444,004 | T/A | — | — |
| rs2485445441 | 7:18,498,484 | A/G | — | likely benign |
| rs213273 | 7:18,504,508 | G/C | — | — |
| rs199565230 | 7:18,535,940 | C/G | — | uncertain significance |
| rs376682964 | 7:18,624,987 | G/A | — | uncertain significance |
| rs200990910 | 7:18,629,980 | A/G | — | uncertain significance |
| rs766827926 | 7:18,630,009 | G/C | — | uncertain significance |
| rs1036752705 | 7:18,630,062 | G/C | — | uncertain significance |
| rs1410934368 | 7:18,631,210 | A/G | — | uncertain significance |
| rs140585698 | 7:18,631,217 | C/G | — | likely benign |
| rs150067220 | 7:18,631,275 | A/G | — | benign |
| rs374092768 | 7:18,669,020 | G/A | — | uncertain significance |
| rs1181444955 | 7:18,669,082 | G/C | — | uncertain significance |
| rs76872642 | 7:18,669,403 | G/A | intron variant | — |
| rs374343180 | 7:18,674,282 | G/T | — | uncertain significance |
| rs765515793 | 7:18,674,346 | C/T | — | uncertain significance |
| rs201873826 | 7:18,674,363 | G/A | — | uncertain significance |
| rs1383184016 | 7:18,684,336 | A/G | — | uncertain significance |
| rs755314928 | 7:18,684,396 | G/T | — | uncertain significance |
| rs367766754 | 7:18,687,445 | C/T | — | uncertain significance |
| rs771090434 | 7:18,687,500 | G/A | — | likely benign |
| rs770206985 | 7:18,687,516 | C/G | — | uncertain significance |
| rs35614472 | 7:18,687,542 | A/T | — | benign |
| rs368961811 | 7:18,688,139 | T/G | — | uncertain significance |
| rs764185312 | 7:18,688,173 | G/A | — | uncertain significance |
| rs73683128 | 7:18,697,667 | T/A | intron variant | — |
| rs79524815 | 7:18,698,331 | T/G | intron variant | — |
| rs1245486363 | 7:18,705,882 | T/C | — | uncertain significance |
| rs765164988 | 7:18,706,002 | T/G | — | uncertain significance |
| rs750018217 | 7:18,706,041 | A/T | — | uncertain significance |
| rs755623800 | 7:18,706,042 | T/A | — | uncertain significance |
| rs73313346 | 7:18,723,232 | T/C | intron variant | — |
| rs1178101 | 7:18,737,197 | C/A | intron variant | — |
| rs6968715 | 7:18,740,554 | T/G | intron variant | — |
| rs114662881 | 7:18,767,219 | C/A | — | benign |
| rs773611939 | 7:18,767,254 | C/G | — | uncertain significance |
| rs1785667050 | 7:18,767,329 | G/C | — | uncertain significance |
| rs1178127 | 7:18,767,343 | G/A | — | benign |
| rs988408353 | 7:18,767,344 | G/T | — | uncertain significance |
| rs915091899 | 7:18,767,345 | C/T | — | uncertain significance |
| rs2483732379 | 7:18,767,348 | T/A | — | uncertain significance |
| rs727851 | 7:18,786,817 | G/A | — | — |
| rs149000625 | 7:18,788,624 | A/G | — | benign |
| rs2483951165 | 7:18,788,626 | A/G | — | uncertain significance |
| rs11764116 | 7:18,800,413 | G/A | — | — |
| rs2484063448 | 7:18,801,813 | A/G | — | uncertain significance |
| rs914541623 | 7:18,801,856 | C/G | — | uncertain significance |
| rs146469500 | 7:18,806,745 | G/A | — | benign |
| rs2484321425 | 7:18,832,999 | A/C | — | uncertain significance |
| rs2484321522 | 7:18,833,005 | C/G | — | uncertain significance |
| rs2484321616 | 7:18,833,010 | G/A | — | uncertain significance |
| rs1060499865 | 7:18,833,039 | C/T | — | likely benign |
| rs188666461 | 7:18,869,079 | C/T | — | benign |
| rs777726008 | 7:18,869,135 | C/A | — | uncertain significance |
| rs762998657 | 7:18,869,142 | A/C | — | uncertain significance |
| rs2073963 | 7:18,877,874 | T/G | intron variant | — |
| rs71530654 | 7:18,896,988 | A/G | intron variant | — |
| rs533506047 | 7:18,917,999 | G/A | — | — |
| rs143455326 | 7:18,968,272 | G/T | intron variant | — |
| rs2389995 | 7:18,973,018 | A/T | — | — |
| rs2240419 | 7:18,975,189 | T/C | intron variant | — |
| rs199497912 | 7:18,975,447 | C/T | — | uncertain significance |
| rs1585350848 | 7:18,975,483 | T/C | — | uncertain significance |
| rs2853552 | 7:18,980,267 | A/T | — | — |
| rs138163349 | 7:18,993,842 | T/C | — | benign |
| rs2389998 | 7:18,993,870 | T/C | — | benign |
| rs56268228 | 7:19,015,338 | A/C | — | benign |
| rs1554416862 | 7:19,015,494 | T/G | — | uncertain significance |
| rs1784519529 | 7:19,015,572 | A/C | — | uncertain significance |
| rs2717350 | 7:19,021,073 | A/T | — | — |
| rs4721737 | 7:19,031,059 | G/A | intron variant | — |
| rs11984041 | 7:19,031,935 | C/T | intron variant | — |
| rs2023938 | 7:19,036,775 | T/C | downstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.