HEG1

heart development protein with EGF like domains 1

Summary

Predicted to enable calcium ion binding activity. Involved in several processes, including negative regulation of Rho protein signal transduction; negative regulation of Rho-dependent protein serine/threonine kinase activity; and negative regulation of membrane permeability. Located in cell-cell junction. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants86 total

rsidPosition (GRCh37)AllelesClassClinVar
rs5467087603:124,689,539G/Auncertain significance
rs9230942013:124,689,545T/Cuncertain significance
rs1862552393:124,689,598C/Tlikely benign
rs7758773553:124,689,609C/Tuncertain significance
rs7641126153:124,689,614C/Tuncertain significance
rs7674153483:124,689,627G/Tuncertain significance
rs7705478983:124,689,644G/Cuncertain significance
rs2007778963:124,692,579T/Cuncertain significance
rs2004344863:124,692,663C/Tuncertain significance
rs22707783:124,692,689C/Asynonymous variant
rs11598183793:124,692,720A/Guncertain significance
rs24724599863:124,692,721T/Cuncertain significance
rs2019105853:124,696,725C/Tuncertain significance
rs24724635613:124,696,728T/Cuncertain significance
rs98362243:124,697,992C/Tintron variant
rs117135663:124,699,908C/A
rs67638113:124,702,307C/Tintron variant
rs615464963:124,706,862A/T
rs3766493153:124,716,574G/Auncertain significance
rs5766507923:124,716,649C/Tuncertain significance
rs1810227333:124,716,667G/Auncertain significance
rs3765372993:124,720,708G/Auncertain significance
rs19370060733:124,720,775C/Guncertain significance
rs7616627693:124,720,797G/Auncertain significance
rs1891399993:124,724,173A/Cuncertain significance
rs64388683:124,728,472C/Gintron variant
rs7798838343:124,728,575T/Guncertain significance
rs5342046023:124,728,650G/Alikely benign
rs14194061293:124,728,668T/Cuncertain significance
rs5532198443:124,731,529G/Cuncertain significance
rs1478858953:124,731,553G/Abenign
rs5652913463:124,731,581G/Auncertain significance
rs2004560043:124,731,628C/Auncertain significance
rs21077005723:124,731,739G/Auncertain significance
rs3775179943:124,731,747T/Glikely benign
rs2014383803:124,731,812T/Cuncertain significance
rs7604758503:124,731,878T/Auncertain significance
rs24725015803:124,731,901G/Auncertain significance
rs10133307463:124,731,918T/Auncertain significance
rs5454713643:124,731,923T/Cuncertain significance
rs2016063973:124,731,991G/Auncertain significance
rs7778796293:124,732,010A/Tuncertain significance
rs1867672643:124,732,292G/Cuncertain significance
rs13601600803:124,732,318A/Guncertain significance
rs3741798143:124,732,339G/Auncertain significance
rs1138388483:124,732,426G/Abenign
rs7496161213:124,732,543A/Guncertain significance
rs3680378353:124,732,567G/Auncertain significance
rs24725028433:124,732,681A/Cuncertain significance
rs7724008493:124,732,726C/Tuncertain significance
rs1146811563:124,732,739T/Abenign
rs7628649563:124,732,748A/Guncertain significance
rs7638991543:124,732,751A/Cuncertain significance
rs5736025513:124,732,775C/Tuncertain significance
rs13233374743:124,732,784T/Auncertain significance
rs3719228383:124,732,832C/Auncertain significance
rs14511005393:124,738,111C/Tuncertain significance
rs5682686143:124,738,120C/Tuncertain significance
rs3692603263:124,738,121G/Auncertain significance
rs2009374223:124,738,283C/Tuncertain significance
rs7610947973:124,738,355C/Tuncertain significance
rs3725686853:124,739,642A/Tuncertain significance
rs7579385153:124,739,689G/Cuncertain significance
rs3762802923:124,739,926G/Auncertain significance
rs7471753823:124,739,950T/Cuncertain significance
rs7499346393:124,746,081G/Auncertain significance
rs7520555123:124,746,144G/Alikely benign
rs617509083:124,746,146G/Alikely benign
rs23330413:124,746,182C/Tbenign
rs2022048643:124,746,195G/Auncertain significance
rs5297624533:124,746,251C/Auncertain significance
rs7735026613:124,748,042A/Tuncertain significance
rs19374598973:124,748,053T/Cuncertain significance
rs1998180513:124,748,159C/Tlikely benign
rs1851965963:124,748,236G/Auncertain significance
rs8957747023:124,774,439G/Tuncertain significance
rs7470104253:124,774,467C/Tuncertain significance
rs11778549473:124,774,491A/Glikely benign
rs16532145713:124,774,506T/Guncertain significance
rs9764742203:124,774,518G/Auncertain significance
rs19379221623:124,774,530G/Auncertain significance
rs12791415953:124,774,548C/Tuncertain significance
rs13929342413:124,774,584C/Tuncertain significance
rs10143017963:124,774,613G/Auncertain significance
rs19379266423:124,774,647T/Guncertain significance
rs12315897243:124,774,659C/Guncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.