HGF

hepatocyte growth factor

Summary

This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss. [provided by RefSeq, Nov 2015]

Known Variants220 total

rsidPosition (GRCh37)AllelesClassClinVar
rs17437:81,328,481A/C——
rs1493515917:81,329,063G/A——
rs47324027:81,330,380C/G3 prime UTR variant—
rs57457687:81,331,430T/C—likely benign
rs1820575477:81,331,501T/A—uncertain significance
rs8860624567:81,331,796T/C—uncertain significance
rs7475164237:81,331,901G/T—uncertain significance
rs1407906657:81,331,905G/A—conflicting classifications of pathogenicity
rs14809500837:81,331,938T/G—uncertain significance
rs25352097157:81,331,943T/C—uncertain significance
rs7630724127:81,331,961C/T—uncertain significance
rs7639332677:81,331,979C/T—uncertain significance
rs3723664087:81,331,989T/C—uncertain significance
rs5438279017:81,332,000C/T—uncertain significance
rs3678004147:81,332,065A/G—conflicting classifications of pathogenicity
rs15839099407:81,332,068A/G—likely benign
rs21157431027:81,332,073C/G—uncertain significance
rs57457677:81,332,105A/C—likely benign
rs782915527:81,332,123G/T—likely benign
rs57457667:81,332,151G/T—benign
rs57457657:81,332,213C/T—likely benign
rs57457647:81,332,233T/C—likely benign
rs7459424617:81,334,700T/C—likely benign
rs7695806287:81,334,735C/T—uncertain significance
rs21157604677:81,334,765T/A—uncertain significance
rs1501095637:81,334,774C/T—uncertain significance
rs2022157007:81,334,782T/C—uncertain significance
rs5650567807:81,334,812T/C—uncertain significance
rs1454942487:81,334,825C/T—conflicting classifications of pathogenicity
rs7627218257:81,334,832T/C—likely benign
rs15839136287:81,334,855G/A—likely benign
rs7794955097:81,334,863C/T—likely benign
rs7646955737:81,334,868A/C—likely benign
rs1417745177:81,334,995C/G—conflicting classifications of pathogenicity
rs7624455457:81,335,009A/G—likely benign
rs7658905007:81,335,011T/C—uncertain significance
rs1470758067:81,335,013G/A—conflicting classifications of pathogenicity
rs21157661187:81,335,017A/G—uncertain significance
rs7664935857:81,335,039C/T—likely benign
rs21157668827:81,335,059G/C—uncertain significance
rs5384154527:81,335,062C/T—conflicting classifications of pathogenicity
rs7456489757:81,335,077C/T—likely benign
rs25352174847:81,335,085A/G—likely benign
rs57457547:81,335,330G/T—likely benign
rs57457527:81,335,460T/C—benign
rs17894247487:81,335,625G/C—uncertain significance
rs25352187687:81,335,627T/A—uncertain significance
rs7667698387:81,335,645T/C—uncertain significance
rs1385480037:81,335,656G/A—likely benign
rs5599904587:81,335,675T/C—uncertain significance
rs21157716337:81,335,683C/G—uncertain significance
rs7787041527:81,335,685C/T—uncertain significance
rs17894276427:81,335,694T/C—uncertain significance
rs1480984797:81,335,698G/A—likely benign
rs7694389087:81,335,733C/A—conflicting classifications of pathogenicity
rs7711512367:81,335,763T/A—likely benign
rs746580557:81,335,777A/G—likely benign
rs57457517:81,335,897C/G—likely benign
rs57457507:81,335,918A/C—likely benign
rs57457497:81,336,032T/G—likely benign
rs20747247:81,336,265C/Tintron variant—
rs57457467:81,336,439T/C—benign
rs57457457:81,336,535A/C—benign
rs1502724587:81,336,584A/G—likely benign
rs25352208317:81,336,592T/A—likely benign
rs3711391297:81,336,597A/G—likely benign
rs21157786797:81,336,617A/G—likely benign
rs13147757067:81,336,620C/G—uncertain significance
rs14187487017:81,336,627G/A—uncertain significance
rs57457437:81,336,894A/C—likely benign
rs764805537:81,339,207C/T—benign
rs57457407:81,339,242A/G—likely benign
rs20747257:81,339,304A/C—benign
rs8766578317:81,339,464T/C—uncertain significance
rs3720751147:81,339,534C/T—likely benign
rs11925833987:81,339,535G/A—uncertain significance
rs3975164467:81,339,550A/G—uncertain significance
rs7784279827:81,339,577A/G—likely benign
rs777306587:81,339,711C/T—likely benign
rs733793597:81,340,507G/A—likely benign
rs1486122847:81,340,515C/T—likely benign
rs3704192437:81,340,790T/A—likely benign
rs21158064487:81,340,820G/T—uncertain significance
rs15543639117:81,340,838G/A—likely benign
rs3748205057:81,340,845T/C—likely benign
rs57457257:81,346,292G/A—benign
rs57457247:81,346,420G/A—benign
rs7485930857:81,346,528C/G—likely benign
rs21158479477:81,346,537A/G—likely benign
rs1482934117:81,346,550C/T—uncertain significance
rs14499649737:81,346,581G/A—uncertain significance
rs17897385717:81,346,610T/C—uncertain significance
rs12284519587:81,346,658G/A—uncertain significance
rs13004294007:81,346,667T/C—uncertain significance
rs7554162767:81,346,678A/G—likely benign
rs25352416617:81,346,679T/A—uncertain significance
rs25352416687:81,346,681A/G—uncertain significance
rs18007937:81,346,685T/C—likely benign
rs2019440347:81,346,698C/A—likely benign
rs57457227:81,346,801T/C—likely benign

Showing 100 of 220 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.