HMGCLL1

3-hydroxy-3-methylglutaryl-CoA lyase like 1

Summary

Enables hydroxymethylglutaryl-CoA lyase activity. Involved in ketone body biosynthetic process. Located in several cellular components, including cytosol; endoplasmic reticulum; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants35 total

rsidPosition (GRCh37)AllelesClassClinVar
rs3733594196:55,300,473G/Auncertain significance
rs2012462836:55,300,540T/Auncertain significance
rs5304465446:55,301,146C/A
rs7641668296:55,304,270C/Tuncertain significance
rs7619977066:55,304,273C/Tuncertain significance
rs7634937436:55,304,300T/Cuncertain significance
rs8967181166:55,304,342C/Tuncertain significance
rs2014564106:55,360,227G/Auncertain significance
rs7609176676:55,360,228T/Auncertain significance
rs7527168876:55,360,290G/Tuncertain significance
rs5310121946:55,360,336G/Cuncertain significance
rs3728065026:55,360,351T/Cuncertain significance
rs3772325026:55,360,360C/Tuncertain significance
rs3710525366:55,360,394T/Auncertain significance
rs5500272236:55,360,715C/T
rs7598177826:55,378,870C/Tuncertain significance
rs13801650536:55,378,874C/Tuncertain significance
rs7707051396:55,378,932C/Auncertain significance
rs13463614946:55,378,948T/Guncertain significance
rs14266855546:55,378,988C/Guncertain significance
rs2008296396:55,381,350G/Auncertain significance
rs1996038986:55,406,540C/Auncertain significance
rs14053071366:55,406,546G/Auncertain significance
rs13044299596:55,406,559T/Auncertain significance
rs3761912216:55,406,565C/Guncertain significance
rs2016039616:55,406,881T/Auncertain significance
rs11791742876:55,406,884G/Cuncertain significance
rs77557096:55,423,717C/Tintron variant
rs1475465366:55,436,342G/Aintron variant
rs117545096:55,473,294A/Gintergenic variant
rs2020031746:55,512,983T/C
rs1859265996:55,524,042A/Gintergenic variant
rs117533706:55,531,243A/Gintergenic variant
rs729750886:55,535,375A/Tintergenic variant
rs47155616:55,541,417C/Adownstream gene variant

Gene information from NCBI Gene. Variant classifications from ClinVar.