HNRNPA0
heterogeneous nuclear ribonucleoprotein A0
Summary
This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind RNAs, followed by a glycine-rich C-terminus. [provided by RefSeq, Jul 2008]
Known Variants10 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs766634666 | 5:137,089,097 | T/A | — | uncertain significance |
| rs754153801 | 5:137,089,100 | C/T | — | uncertain significance |
| rs1256836820 | 5:137,089,106 | T/A | — | uncertain significance |
| rs1016710116 | 5:137,089,143 | C/A | — | uncertain significance |
| rs1047218621 | 5:137,089,149 | C/T | — | uncertain significance |
| rs371814036 | 5:137,089,176 | C/A | — | uncertain significance |
| rs75922891 | 5:137,089,240 | T/C | — | benign |
| rs763263823 | 5:137,089,374 | C/G | — | uncertain significance |
| rs2531873752 | 5:137,089,407 | G/A | — | uncertain significance |
| rs56210945 | 5:137,091,161 | C/A | upstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.