HOXA11

homeobox A11

Summary

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia. [provided by RefSeq, Jul 2008]

Known Variants49 total

rsidPosition (GRCh37)AllelesClassClinVar
rs174278617:27,222,409A/Glikely benign
rs25348033647:27,222,476A/Clikely pathogenic
rs1158087037:27,222,517G/Alikely benign
rs25348034537:27,222,538T/Auncertain significance
rs25348035157:27,222,582C/Tlikely pathogenic
rs17837948787:27,222,642G/Tuncertain significance
rs3772025147:27,222,643G/Tlikely benign
rs78015817:27,223,771T/Cbenign
rs13833377697:27,224,061C/Auncertain significance
rs7718599687:27,224,085C/Guncertain significance
rs10853077237:27,224,139C/Tuncertain significance
rs5539907937:27,224,155C/Alikely benign
rs11657671947:27,224,160C/Guncertain significance
rs9912705827:27,224,169C/Auncertain significance
rs9310003537:27,224,204G/Cuncertain significance
rs25348064917:27,224,207G/Tuncertain significance
rs25348065017:27,224,210C/Tuncertain significance
rs9088370657:27,224,232C/Tuncertain significance
rs5625279557:27,224,245C/Alikely benign
rs7752233857:27,224,252G/Tlikely benign
rs12665328597:27,224,255G/Tuncertain significance
rs7679533007:27,224,256G/Auncertain significance
rs12634506497:27,224,261C/Auncertain significance
rs17838312467:27,224,270G/Tuncertain significance
rs8937929327:27,224,275C/Gbenign
rs7765617567:27,224,305G/Tuncertain significance
rs17838326817:27,224,313G/Tuncertain significance
rs1438126367:27,224,368C/Gconflicting classifications of pathogenicity
rs25348069087:27,224,373C/Tuncertain significance
rs7599950277:27,224,391T/Guncertain significance
rs21154628737:27,224,411G/Auncertain significance
rs3729377447:27,224,416G/Cuncertain significance
rs21154628917:27,224,424C/Tuncertain significance
rs9261079517:27,224,432G/Auncertain significance
rs7769029597:27,224,436T/Cuncertain significance
rs7800702067:27,224,460C/Tuncertain significance
rs7716746237:27,224,469C/Tlikely benign
rs2003840707:27,224,478C/Tuncertain significance
rs7784674387:27,224,516T/Cuncertain significance
rs1391022187:27,224,526C/Tbenign
rs2017620927:27,224,528A/Glikely benign
rs7497631847:27,224,541G/Tuncertain significance
rs7692000947:27,224,542G/Tuncertain significance
rs21154631657:27,224,595C/Tuncertain significance
rs1505693167:27,224,612A/Tuncertain significance
rs12622831207:27,224,615T/Cuncertain significance
rs3739289927:27,224,640G/Cuncertain significance
rs7525259997:27,224,754C/Guncertain significance
rs174374957:27,224,963C/Tbenign

Gene information from NCBI Gene. Variant classifications from ClinVar.