HRC

histidine rich calcium binding protein

Summary

This gene encodes a luminal sarcoplasmic reticulum protein identified by its ability to bind low-density lipoprotein with high affinity. The protein interacts with the cytoplasmic domain of triadin, the main transmembrane protein of the junctional sarcoplasmic reticulum (SR) of skeletal muscle. The protein functions in the regulation of releasable calcium into the SR. [provided by RefSeq, Sep 2008]

Known Variants45 total

rsidPosition (GRCh37)AllelesClassClinVar
rs15061144619:49,654,561C/Glikely benign
rs77403584319:49,655,301G/Cuncertain significance
rs147053636419:49,655,590C/Guncertain significance
rs37386983319:49,656,546G/Cuncertain significance
rs100683116419:49,656,573T/Cuncertain significance
rs76886187219:49,656,676C/Tuncertain significance
rs6173282919:49,656,688C/Tbenign
rs14408914319:49,656,807C/Tuncertain significance
rs92711390419:49,656,928C/Tuncertain significance
rs15113720319:49,656,955G/Cuncertain significance
rs204138475419:49,656,963T/Cuncertain significance
rs204138531319:49,657,014G/Tuncertain significance
rs14399580419:49,657,018C/Tlikely benign
rs14090490919:49,657,075T/Cuncertain significance
rs57009683919:49,657,197T/Auncertain significance
rs117209692719:49,657,285C/Tuncertain significance
rs75116277119:49,657,328G/Cuncertain significance
rs77750948219:49,657,344G/Auncertain significance
rs75916359419:49,657,413C/Tlikely benign
rs77495939619:49,657,489G/Auncertain significance
rs251401005019:49,657,536C/Tuncertain significance
rs204139276219:49,657,552C/Tuncertain significance
rs14643780719:49,657,602C/Tlikely benign
rs15117596319:49,657,626T/Cuncertain significance
rs251401077819:49,657,725T/Cuncertain significance
rs76645097419:49,657,778C/Auncertain significance
rs118638292219:49,657,789G/Auncertain significance
rs75648537619:49,657,799A/Glikely benign
rs74545240719:49,657,811T/Glikely benign
rs14967148419:49,657,845C/Tlikely benign
rs19294929819:49,657,930C/Tuncertain significance
rs11170176619:49,657,939C/Guncertain significance
rs53465126219:49,657,947C/Tuncertain significance
rs75108631819:49,658,008C/Tuncertain significance
rs75581284019:49,658,023G/Auncertain significance
rs20070171219:49,658,053G/Auncertain significance
rs14184082319:49,658,121G/Auncertain significance
rs75527865219:49,658,144A/Glikely benign
rs101723390619:49,658,200A/Guncertain significance
rs7466614719:49,658,204C/Tlikely benign
rs374529719:49,658,209C/Abenign
rs14896678519:49,658,233G/Amissense variant
rs55053437319:49,658,299C/Tlikely benign
rs131196069419:49,658,331G/Tuncertain significance
rs13805942019:49,658,344C/Tuncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.