HS6ST1

heparan sulfate 6-O-sulfotransferase 1

Summary

The protein encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biological activities. This enzyme is a type II integral membrane protein and is responsible for 6-O-sulfation of heparan sulfate. This enzyme does not share significant sequence similarity with other known sulfotransferases. A pseudogene located on chromosome 1 has been found for this gene. [provided by RefSeq, Jul 2008]

Known Variants119 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs2290113	2:129,024,313	A/G	3 prime UTR variant	—
rs71420833	2:129,025,396	G/A	—	likely benign
rs4662597	2:129,025,468	C/G	—	likely benign
rs13385129	2:129,025,619	T/C	—	benign
rs112636716	2:129,025,705	C/G	—	benign
rs748882699	2:129,025,754	G/C	—	uncertain significance
rs2104908339	2:129,025,759	T/C	—	uncertain significance
rs2104908342	2:129,025,762	T/C	—	risk factor
rs1263025168	2:129,025,771	C/T	—	uncertain significance
rs374582641	2:129,025,772	G/A	—	likely benign
rs370255491	2:129,025,778	C/T	—	conflicting classifications of pathogenicity
rs1693552883	2:129,025,779	A/G	—	uncertain significance
rs533654326	2:129,025,781	G/A	—	likely benign
rs765444171	2:129,025,786	C/A	—	uncertain significance
rs766927296	2:129,025,788	G/A	—	uncertain significance
rs201160903	2:129,025,795	C/T	—	benign
rs557526954	2:129,025,827	C/T	—	uncertain significance
rs199538589	2:129,025,828	G/A	missense variant	risk factor
rs368742889	2:129,025,839	C/T	—	uncertain significance
rs202155445	2:129,025,847	G/A	—	likely benign
rs182882999	2:129,025,848	C/T	—	uncertain significance
rs559410305	2:129,025,849	G/A	—	uncertain significance
rs61732021	2:129,025,851	C/T	—	conflicting classifications of pathogenicity
rs147436494	2:129,025,860	C/T	—	likely benign
rs372735853	2:129,025,861	G/A	—	uncertain significance
rs376288417	2:129,025,872	C/T	—	uncertain significance
rs369568256	2:129,025,873	G/A	—	uncertain significance
rs2104908476	2:129,025,895	G/A	—	uncertain significance
rs541648176	2:129,025,922	G/A	—	likely benign
rs2467761863	2:129,025,952	G/C	—	likely benign
rs761125600	2:129,025,955	C/A	—	uncertain significance
rs533693492	2:129,025,960	C/T	—	uncertain significance
rs1374891155	2:129,025,968	C/T	—	uncertain significance
rs771013218	2:129,025,987	C/T	—	uncertain significance
rs777602833	2:129,025,993	C/T	—	uncertain significance
rs761325768	2:129,026,004	C/T	—	risk factor
rs1693560929	2:129,026,017	A/T	—	uncertain significance
rs549061344	2:129,026,031	C/T	—	uncertain significance
rs777732997	2:129,026,046	T/C	—	uncertain significance
rs372108639	2:129,026,052	G/A	—	uncertain significance
rs201307896	2:129,026,055	C/T	—	uncertain significance
rs780352591	2:129,026,056	G/A	—	uncertain significance
rs367706063	2:129,026,060	G/A	—	likely benign
rs2467762181	2:129,026,081	C/T	—	likely benign
rs375220930	2:129,026,090	G/A	—	likely benign
rs2104908742	2:129,026,093	C/T	—	likely benign
rs369549797	2:129,026,099	G/A	—	benign
rs556856038	2:129,026,115	C/T	—	uncertain significance
rs2104908773	2:129,026,124	T/C	—	uncertain significance
rs567411064	2:129,026,132	G/A	—	benign
rs536289777	2:129,026,138	G/A	—	likely benign
rs376369605	2:129,026,144	C/G	—	benign
rs377006394	2:129,026,165	G/A	—	likely benign
rs1558866400	2:129,026,170	T/C	—	uncertain significance
rs369582414	2:129,026,207	G/A	—	likely benign
rs1278055169	2:129,026,226	C/T	—	uncertain significance
rs3958533	2:129,026,227	G/T	—	likely benign
rs377558103	2:129,026,240	G/A	—	likely benign
rs578226421	2:129,026,247	G/A	—	uncertain significance
rs200656779	2:129,026,249	G/A	—	likely benign
rs201752744	2:129,026,270	C/T	—	likely benign
rs748170962	2:129,026,271	G/A	—	uncertain significance
rs199688175	2:129,026,297	G/A	—	benign
rs200268730	2:129,026,320	G/A	—	conflicting classifications of pathogenicity
rs755290912	2:129,026,322	G/A	—	uncertain significance
rs368934572	2:129,026,328	G/A	—	uncertain significance
rs749738599	2:129,026,331	C/T	—	uncertain significance
rs2467762748	2:129,026,380	C/T	—	uncertain significance
rs200713281	2:129,026,411	G/A	—	likely benign
rs750823789	2:129,026,456	C/T	—	likely benign
rs35313751	2:129,026,457	A/G	—	benign
rs73956956	2:129,026,512	T/C	—	likely benign
rs77283666	2:129,026,622	T/C	—	benign
rs146616866	2:129,026,718	T/G	—	likely benign
rs6431005	2:129,026,749	A/G	—	benign
rs11885153	2:129,026,777	G/A	—	benign
rs2084498	2:129,048,433	A/T	—	—
rs142919287	2:129,066,114	C/T	intron variant	—
rs116546879	2:129,075,342	C/T	—	benign
rs183078127	2:129,075,508	G/T	—	likely benign
rs534608659	2:129,075,602	G/A	—	likely benign
rs2104941530	2:129,075,720	G/C	—	uncertain significance
rs543138462	2:129,075,733	A/T	—	likely benign
rs745851677	2:129,075,778	G/T	—	likely benign
rs772042817	2:129,075,790	G/A	—	likely benign
rs1694402952	2:129,075,794	G/T	—	uncertain significance
rs199993343	2:129,075,797	A/C	—	benign
rs576560062	2:129,075,802	G/C	—	benign
rs2467824726	2:129,075,823	G/C	—	uncertain significance
rs1694404029	2:129,075,843	C/T	—	uncertain significance
rs768891596	2:129,075,847	C/A	—	likely benign
rs200979099	2:129,075,877	G/T	—	likely benign
rs745353899	2:129,075,904	C/G	—	likely benign
rs879255383	2:129,075,905	G/A	—	uncertain significance
rs61732019	2:129,075,919	G/A	—	benign
rs773201976	2:129,075,932	T/C	—	uncertain significance
rs766815438	2:129,075,937	C/T	—	likely benign
rs759982406	2:129,075,940	C/T	—	likely benign
rs61732017	2:129,075,951	G/T	—	uncertain significance
rs746894917	2:129,075,960	G/A	—	uncertain significance

Showing 100 of 119 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.