HSBP1

heat shock factor binding protein 1

Summary

The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response. [provided by RefSeq, Jul 2008]

Known Variants10 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs11149602	16:83,841,213	T/G	—	benign
rs3743623	16:83,841,560	G/T	—	benign
rs76191599	16:83,842,521	C/A	—	benign
rs8053753	16:83,842,792	T/G	—	benign
rs77309135	16:83,842,844	G/C	—	benign
rs183063080	16:83,842,969	C/G	—	uncertain significance
rs1404463667	16:83,843,009	C/G	—	uncertain significance
rs139083167	16:83,843,326	G/C	—	benign
rs8048380	16:83,850,714	A/G	downstream gene variant	—
rs181196574	16:83,853,376	T/G	downstream gene variant	—

Gene information from NCBI Gene. Variant classifications from ClinVar.