HSD3B1

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

Summary

The protein encoded by this gene is an enzyme that catalyzes the oxidative conversion of delta-5-3-beta-hydroxysteroid precursors into delta-4-ketosteroids, which leads to the production of all classes of steroid hormones. The encoded protein also catalyzes the interconversion of 3-beta-hydroxy- and 3-keto-5-alpha-androstane steroids. [provided by RefSeq, Jun 2016]

Known Variants39 total

rsidPosition (GRCh37)AllelesClassClinVar
rs7636580661:120,050,125C/Guncertain significance
rs5877433001:120,050,137G/Tuncertain significance
rs5876704611:120,050,160C/Tuncertain significance
rs1456985161:120,050,161G/Auncertain significance
rs25258985601:120,050,197G/Cuncertain significance
rs1442619941:120,050,210G/Cuncertain significance
rs37659451:120,051,446G/C
rs1380253031:120,054,190G/Cuncertain significance
rs3758329911:120,054,206G/Alikely benign
rs5876097841:120,054,212G/Tuncertain significance
rs62011:120,054,215A/Gbenign
rs3776552831:120,054,227G/Auncertain significance
rs5877153301:120,054,259C/Guncertain significance
rs64288301:120,054,775A/C
rs1480578091:120,056,534G/Auncertain significance
rs1996741021:120,056,582C/Tuncertain significance
rs7572628841:120,056,649C/Tuncertain significance
rs7571351871:120,056,675G/Auncertain significance
rs15578969861:120,056,811A/Guncertain significance
rs7747381581:120,056,820A/Guncertain significance
rs5877765031:120,056,858A/Tnot provided
rs25259158031:120,056,865T/Auncertain significance
rs3686935361:120,056,882G/Tuncertain significance
rs7712045561:120,056,883C/Tuncertain significance
rs16540374271:120,056,888A/Guncertain significance
rs7726881261:120,056,895G/Alikely benign
rs7660740411:120,056,930C/Tuncertain significance
rs12352719591:120,056,968A/Cuncertain significance
rs3777039421:120,056,975G/Tuncertain significance
rs7650771901:120,056,981C/Tlikely benign
rs25259162661:120,057,000G/Auncertain significance
rs7761517471:120,057,001C/Auncertain significance
rs7475010931:120,057,081G/Alikely benign
rs5877648531:120,057,095C/Auncertain significance
rs62031:120,057,158C/Gmissense variant
rs7814867951:120,057,186A/Guncertain significance
rs16540551151:120,057,189A/Guncertain significance
rs10473031:120,057,246C/Amissense variantdrug response
rs25259172521:120,057,259G/Tuncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.