HSPA4
heat shock protein family A (Hsp70) member 4
Summary
Predicted to enable adenyl-nucleotide exchange factor activity. Involved in chaperone-mediated protein complex assembly and protein insertion into mitochondrial outer membrane. Located in cytosol and extracellular exosome. Implicated in Chagas disease. Biomarker of chronic obstructive pulmonary disease; rheumatoid arthritis; type 2 diabetes mellitus; and ulcerative colitis. [provided by Alliance of Genome Resources, Apr 2025]
Known Variants56 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs7712182 | 5:132,386,242 | T/A | regulatory region variant | — |
| rs143631835 | 5:132,388,038 | C/T | — | benign |
| rs72801445 | 5:132,388,959 | C/T | intron variant | — |
| rs55914434 | 5:132,395,537 | T/G | intron variant | — |
| rs201681457 | 5:132,402,435 | T/C | — | — |
| rs1765321513 | 5:132,403,134 | T/C | — | uncertain significance |
| rs6596099 | 5:132,403,359 | T/A | intron variant | — |
| rs56306291 | 5:132,404,947 | T/A | intron variant | — |
| rs72801454 | 5:132,405,885 | A/T | intron variant | — |
| rs1459462893 | 5:132,406,070 | C/A | — | likely benign |
| rs748793300 | 5:132,406,075 | A/T | — | uncertain significance |
| rs6596100 | 5:132,407,058 | C/T | intron variant | — |
| rs145291096 | 5:132,408,945 | A/G | — | benign |
| rs185385178 | 5:132,409,020 | A/G | — | likely benign |
| rs56121115 | 5:132,409,074 | A/G | intron variant | — |
| rs115939709 | 5:132,409,749 | A/C | — | benign |
| rs6892902 | 5:132,411,431 | G/C | — | — |
| rs78942185 | 5:132,412,342 | T/A | — | benign |
| rs139928038 | 5:132,412,368 | C/T | — | uncertain significance |
| rs145548542 | 5:132,412,508 | T/C | — | benign |
| rs931329734 | 5:132,412,511 | A/T | — | uncertain significance |
| rs76495289 | 5:132,418,974 | A/T | intron variant | — |
| rs1322707009 | 5:132,422,534 | T/G | — | uncertain significance |
| rs902604170 | 5:132,424,846 | G/T | — | uncertain significance |
| rs1172188343 | 5:132,425,271 | C/G | — | uncertain significance |
| rs745601546 | 5:132,425,313 | A/G | — | uncertain significance |
| rs1765660557 | 5:132,428,398 | C/G | — | uncertain significance |
| rs1688257832 | 5:132,428,427 | A/T | — | uncertain significance |
| rs116457609 | 5:132,431,780 | A/G | — | benign |
| rs1482072272 | 5:132,431,809 | A/G | — | uncertain significance |
| rs746239326 | 5:132,431,811 | G/A | — | uncertain significance |
| rs377188604 | 5:132,431,880 | A/G | — | uncertain significance |
| rs752253193 | 5:132,431,898 | T/C | — | uncertain significance |
| rs36009159 | 5:132,432,882 | G/A | — | likely benign |
| rs769367849 | 5:132,432,930 | A/T | — | uncertain significance |
| rs62375243 | 5:132,433,297 | G/A | intron variant | — |
| rs753150277 | 5:132,435,252 | A/G | — | uncertain significance |
| rs61755723 | 5:132,435,253 | C/G | — | benign |
| rs200314501 | 5:132,435,268 | A/G | — | uncertain significance |
| rs200858773 | 5:132,437,472 | A/G | — | uncertain significance |
| rs368330661 | 5:132,437,482 | A/G | — | uncertain significance |
| rs61749631 | 5:132,437,499 | C/T | — | likely benign |
| rs2533069329 | 5:132,437,533 | A/C | — | uncertain significance |
| rs62375245 | 5:132,438,358 | C/T | intron variant | — |
| rs62375246 | 5:132,439,010 | T/C | — | — |
| rs62375247 | 5:132,439,028 | C/T | regulatory region variant | — |
| rs1428899801 | 5:132,439,560 | G/T | — | uncertain significance |
| rs762853209 | 5:132,439,567 | A/G | — | uncertain significance |
| rs764045411 | 5:132,439,657 | A/G | — | uncertain significance |
| rs759535353 | 5:132,439,670 | G/C | — | uncertain significance |
| rs148490915 | 5:132,439,700 | G/C | — | uncertain significance |
| rs1474206848 | 5:132,440,066 | G/A | — | uncertain significance |
| rs770596957 | 5:132,440,120 | A/G | — | uncertain significance |
| rs571173399 | 5:132,441,799 | T/A | — | — |
| rs56076449 | 5:132,442,190 | T/G | regulatory region variant | — |
| rs56083805 | 5:132,442,263 | T/C | downstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.