ICAM2
intercellular adhesion molecule 2
Summary
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Known Variants21 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1309730084 | 17:62,080,147 | C/T | — | likely benign |
| rs1274606891 | 17:62,080,151 | C/T | — | uncertain significance |
| rs201009410 | 17:62,080,177 | C/T | — | likely benign |
| rs202007015 | 17:62,080,221 | G/C | — | uncertain significance |
| rs2509373474 | 17:62,080,243 | A/G | — | uncertain significance |
| rs372611066 | 17:62,081,055 | C/T | — | uncertain significance |
| rs149059683 | 17:62,081,169 | C/T | — | uncertain significance |
| rs2509380008 | 17:62,081,222 | C/T | — | uncertain significance |
| rs770462917 | 17:62,081,232 | G/C | — | uncertain significance |
| rs370443111 | 17:62,081,258 | A/G | — | uncertain significance |
| rs1007934102 | 17:62,082,479 | C/T | — | likely benign |
| rs768243019 | 17:62,082,497 | C/T | — | likely benign |
| rs1158996303 | 17:62,082,535 | G/A | — | uncertain significance |
| rs758262793 | 17:62,082,584 | C/T | — | uncertain significance |
| rs763561197 | 17:62,082,662 | C/T | — | uncertain significance |
| rs576041427 | 17:62,082,670 | C/A | — | uncertain significance |
| rs754428044 | 17:62,082,700 | C/T | — | uncertain significance |
| rs780956757 | 17:62,082,704 | C/A | — | uncertain significance |
| rs561724136 | 17:62,083,305 | A/C | — | — |
| rs752187014 | 17:62,084,039 | C/T | — | uncertain significance |
| rs146310098 | 17:62,084,769 | C/G | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.