ICAM4
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
Summary
This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Known Variants24 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs564720444 | 19:10,397,740 | C/T | — | uncertain significance |
| rs762283483 | 19:10,397,742 | G/A | — | uncertain significance |
| rs1248169688 | 19:10,397,815 | G/A | — | uncertain significance |
| rs370626504 | 19:10,397,833 | T/C | — | uncertain significance |
| rs773722481 | 19:10,397,847 | C/A | — | uncertain significance |
| rs141882537 | 19:10,397,870 | C/T | — | uncertain significance |
| rs77493670 | 19:10,397,987 | A/G | missense variant | affects |
| rs755282868 | 19:10,398,062 | C/T | — | uncertain significance |
| rs35165411 | 19:10,398,206 | C/T | coding sequence variant | — |
| rs2512348908 | 19:10,398,239 | C/T | — | uncertain significance |
| rs2512348956 | 19:10,398,281 | T/C | — | uncertain significance |
| rs770792909 | 19:10,398,296 | C/G | — | uncertain significance |
| rs766979276 | 19:10,398,307 | T/A | — | uncertain significance |
| rs907035521 | 19:10,398,325 | C/T | — | uncertain significance |
| rs758847209 | 19:10,398,361 | C/T | — | uncertain significance |
| rs1217291717 | 19:10,398,403 | G/A | — | uncertain significance |
| rs1568297555 | 19:10,398,433 | C/A | — | uncertain significance |
| rs36023325 | 19:10,398,439 | G/C | — | likely benign |
| rs142109230 | 19:10,398,465 | C/T | — | likely benign |
| rs1359584258 | 19:10,398,491 | C/G | — | uncertain significance |
| rs372936502 | 19:10,398,495 | A/C | — | likely benign |
| rs766820266 | 19:10,398,508 | A/G | — | uncertain significance |
| rs750159706 | 19:10,398,673 | G/A | — | uncertain significance |
| rs142025233 | 19:10,399,399 | T/G | coding sequence variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.