ICE2
interactor of little elongation complex ELL subunit 2
Summary
This gene encodes a protein component of the little elongation complex (LEC), which plays a role in small nuclear RNA (snRNA) transcription. The LEC regulates snRNA transcription by enhancing both RNA Polymerase II occupancy and transcriptional elongation. The encoded protein and other LEC components have been shown to localize to Cajal bodies, which are sites of ribonucleoprotein (RNP) complex assembly. Pseudogenes of this gene have been identified on chromosomes 3 and 4. [provided by RefSeq, May 2017]
Known Variants72 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs536947929 | 15:60,714,768 | G/A | — | — |
| rs34293839 | 15:60,715,248 | A/G | regulatory region variant | — |
| rs1046657 | 15:60,715,800 | T/A | — | — |
| rs2505401185 | 15:60,715,859 | C/T | — | uncertain significance |
| rs199727296 | 15:60,715,908 | T/C | — | likely benign |
| rs767356519 | 15:60,715,961 | T/A | — | uncertain significance |
| rs2063385348 | 15:60,720,686 | T/C | — | uncertain significance |
| rs759573972 | 15:60,720,702 | G/A | — | uncertain significance |
| rs117095293 | 15:60,720,819 | A/C | — | likely benign |
| rs754619595 | 15:60,720,872 | G/T | — | uncertain significance |
| rs79167237 | 15:60,724,151 | A/G | — | uncertain significance |
| rs773818451 | 15:60,724,155 | G/T | — | uncertain significance |
| rs375280679 | 15:60,724,193 | A/G | — | likely benign |
| rs1063100 | 15:60,734,697 | A/G | — | benign |
| rs184163975 | 15:60,739,642 | A/G | intron variant | — |
| rs149396486 | 15:60,740,208 | C/G | — | uncertain significance |
| rs769877410 | 15:60,740,231 | G/T | — | uncertain significance |
| rs559027997 | 15:60,741,083 | A/C | — | uncertain significance |
| rs368391917 | 15:60,741,087 | C/T | — | likely benign |
| rs544687567 | 15:60,741,112 | C/T | — | uncertain significance |
| rs768574361 | 15:60,741,151 | T/C | — | uncertain significance |
| rs200403344 | 15:60,741,233 | C/G | — | uncertain significance |
| rs139046429 | 15:60,741,263 | T/C | — | uncertain significance |
| rs1233407860 | 15:60,741,305 | T/C | — | uncertain significance |
| rs2505568983 | 15:60,741,331 | T/C | — | uncertain significance |
| rs771572273 | 15:60,741,415 | C/T | — | uncertain significance |
| rs1415186062 | 15:60,741,424 | T/G | — | uncertain significance |
| rs2505570095 | 15:60,741,435 | A/C | — | uncertain significance |
| rs763524268 | 15:60,741,452 | C/T | — | uncertain significance |
| rs114852352 | 15:60,741,467 | C/T | — | benign |
| rs1595778188 | 15:60,741,510 | C/T | — | likely benign |
| rs2505572085 | 15:60,741,634 | G/C | — | uncertain significance |
| rs2063906754 | 15:60,741,651 | A/G | — | likely benign |
| rs542453190 | 15:60,741,684 | C/G | — | uncertain significance |
| rs143271506 | 15:60,741,703 | C/T | — | likely benign |
| rs186509093 | 15:60,741,765 | C/T | — | likely benign |
| rs567141472 | 15:60,741,817 | G/T | — | uncertain significance |
| rs2063913434 | 15:60,741,844 | G/A | — | uncertain significance |
| rs200818091 | 15:60,741,901 | G/T | — | uncertain significance |
| rs773312605 | 15:60,741,913 | C/T | — | uncertain significance |
| rs766076147 | 15:60,741,924 | T/C | — | likely benign |
| rs139326710 | 15:60,741,931 | T/C | — | uncertain significance |
| rs372693696 | 15:60,741,932 | T/C | — | uncertain significance |
| rs117980613 | 15:60,742,029 | T/C | — | benign |
| rs199560072 | 15:60,745,789 | A/C | — | likely benign |
| rs2505607797 | 15:60,745,974 | G/A | — | uncertain significance |
| rs999661043 | 15:60,746,659 | G/C | — | uncertain significance |
| rs376840012 | 15:60,747,229 | C/G | — | uncertain significance |
| rs1303888688 | 15:60,747,318 | T/C | — | uncertain significance |
| rs745899002 | 15:60,747,524 | C/G | — | uncertain significance |
| rs772036104 | 15:60,747,530 | G/A | — | uncertain significance |
| rs151196206 | 15:60,747,540 | A/G | — | likely benign |
| rs41372146 | 15:60,747,546 | T/A | — | benign |
| rs758428097 | 15:60,747,559 | T/G | — | uncertain significance |
| rs367547422 | 15:60,748,867 | G/A | — | uncertain significance |
| rs2505634615 | 15:60,748,903 | A/T | — | uncertain significance |
| rs538937507 | 15:60,749,443 | C/T | — | — |
| rs761991924 | 15:60,758,806 | C/T | — | uncertain significance |
| rs765501491 | 15:60,758,807 | G/A | — | uncertain significance |
| rs949164821 | 15:60,758,833 | T/A | — | uncertain significance |
| rs145373484 | 15:60,758,892 | G/A | — | benign |
| rs141469235 | 15:60,758,905 | T/C | — | likely benign |
| rs774422711 | 15:60,760,267 | T/C | — | uncertain significance |
| rs760469941 | 15:60,760,414 | A/G | — | uncertain significance |
| rs202144613 | 15:60,760,427 | T/C | — | uncertain significance |
| rs62003261 | 15:60,761,489 | T/C | intron variant | — |
| rs763050034 | 15:60,768,268 | G/A | — | uncertain significance |
| rs368105955 | 15:60,768,278 | G/A | — | likely benign |
| rs2505763455 | 15:60,770,126 | T/A | — | likely benign |
| rs138355312 | 15:60,770,145 | C/T | — | uncertain significance |
| rs781193853 | 15:60,770,158 | T/C | — | uncertain significance |
| rs2505763780 | 15:60,770,164 | T/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.