IFI16
interferon gamma inducible protein 16
Summary
This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011]
Known Variants58 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs4657616 | 1:158,971,086 | A/G | intron variant | — |
| rs889032253 | 1:158,984,633 | A/G | — | uncertain significance |
| rs760760753 | 1:158,984,682 | A/G | — | uncertain significance |
| rs116270651 | 1:158,985,673 | G/A | — | likely benign |
| rs1425349668 | 1:158,985,718 | G/T | — | uncertain significance |
| rs141289651 | 1:158,985,721 | C/G | — | uncertain significance |
| rs772839461 | 1:158,985,725 | C/T | — | uncertain significance |
| rs770613302 | 1:158,985,737 | C/T | — | uncertain significance |
| rs149145965 | 1:158,986,350 | G/C | — | uncertain significance |
| rs1196434208 | 1:158,986,398 | T/G | — | uncertain significance |
| rs778462683 | 1:158,986,413 | G/A | — | likely benign |
| rs1652947593 | 1:158,986,430 | G/A | — | uncertain significance |
| rs751208160 | 1:158,988,023 | C/T | — | uncertain significance |
| rs147795049 | 1:158,988,076 | C/T | — | uncertain significance |
| rs1653087706 | 1:158,988,274 | A/G | — | likely benign |
| rs900365978 | 1:158,988,294 | A/T | — | uncertain significance |
| rs2524916791 | 1:158,988,304 | G/A | — | uncertain significance |
| rs149606671 | 1:158,988,319 | C/A | — | uncertain significance |
| rs765839419 | 1:158,988,337 | G/A | — | uncertain significance |
| rs2524917036 | 1:158,988,345 | T/G | — | uncertain significance |
| rs751992785 | 1:158,988,391 | C/T | — | uncertain significance |
| rs148343140 | 1:158,988,413 | T/C | — | uncertain significance |
| rs147525533 | 1:158,990,148 | G/T | — | uncertain significance |
| rs1653237395 | 1:158,990,209 | T/C | — | uncertain significance |
| rs1653244211 | 1:158,990,270 | A/T | — | uncertain significance |
| rs861318 | 1:159,002,222 | A/C | — | — |
| rs955902025 | 1:159,002,378 | G/A | — | uncertain significance |
| rs763564898 | 1:159,002,432 | G/A | — | likely benign |
| rs150206389 | 1:159,002,477 | C/T | — | likely benign |
| rs72709516 | 1:159,004,851 | C/T | intron variant | — |
| rs1772408 | 1:159,005,649 | A/G | intron variant | — |
| rs1633267 | 1:159,010,220 | T/G | regulatory region variant | — |
| rs145587930 | 1:159,012,491 | A/G | intron variant | — |
| rs764708505 | 1:159,015,102 | A/G | — | uncertain significance |
| rs1654912103 | 1:159,015,157 | T/C | — | uncertain significance |
| rs200732327 | 1:159,015,196 | G/A | — | uncertain significance |
| rs200120060 | 1:159,015,238 | G/A | — | uncertain significance |
| rs147301876 | 1:159,015,250 | C/T | — | benign |
| rs115888957 | 1:159,019,454 | C/T | intron variant | — |
| rs745870911 | 1:159,021,508 | A/G | — | uncertain significance |
| rs752853831 | 1:159,021,587 | A/G | — | uncertain significance |
| rs2525164898 | 1:159,021,599 | T/G | — | uncertain significance |
| rs147125989 | 1:159,021,617 | C/T | — | uncertain significance |
| rs1655380033 | 1:159,021,634 | T/C | — | uncertain significance |
| rs746538717 | 1:159,021,638 | G/A | — | likely benign |
| rs376656720 | 1:159,021,691 | A/T | — | uncertain significance |
| rs202110181 | 1:159,021,697 | A/G | — | uncertain significance |
| rs142716815 | 1:159,021,699 | A/G | — | uncertain significance |
| rs755795460 | 1:159,021,754 | G/A | — | uncertain significance |
| rs371196311 | 1:159,021,871 | G/A | — | uncertain significance |
| rs2525180960 | 1:159,023,389 | G/C | — | uncertain significance |
| rs1655493348 | 1:159,023,399 | G/A | — | uncertain significance |
| rs141780636 | 1:159,023,419 | G/A | — | uncertain significance |
| rs778998782 | 1:159,023,421 | G/T | — | uncertain significance |
| rs202216559 | 1:159,023,422 | G/A | — | uncertain significance |
| rs146249035 | 1:159,024,654 | A/G | — | uncertain significance |
| rs6940 | 1:159,024,668 | A/T | missense variant | benign |
| rs200953915 | 1:159,024,679 | C/G | — | likely benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.