IFNL1
interferon lambda 1
Summary
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 28B (IL28B) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]
Known Variants24 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs112126725 | 19:39,787,083 | G/A | — | uncertain significance |
| rs2513391549 | 19:39,787,141 | C/T | — | uncertain significance |
| rs114823100 | 19:39,787,143 | A/G | — | benign |
| rs201193440 | 19:39,787,153 | G/A | — | uncertain significance |
| rs764666505 | 19:39,787,157 | G/C | — | uncertain significance |
| rs2513391638 | 19:39,787,197 | G/C | — | uncertain significance |
| rs773775294 | 19:39,787,460 | C/A | — | uncertain significance |
| rs145085203 | 19:39,788,614 | G/A | — | uncertain significance |
| rs146702046 | 19:39,788,615 | C/T | — | benign |
| rs150964916 | 19:39,788,648 | G/A | — | benign |
| rs769258923 | 19:39,788,691 | G/A | — | likely benign |
| rs561686249 | 19:39,788,736 | C/T | — | uncertain significance |
| rs2513393231 | 19:39,788,868 | A/G | — | uncertain significance |
| rs201955392 | 19:39,788,877 | C/T | — | uncertain significance |
| rs147395671 | 19:39,788,913 | C/T | — | uncertain significance |
| rs550342787 | 19:39,788,914 | G/C | — | uncertain significance |
| rs779495745 | 19:39,788,935 | A/T | — | uncertain significance |
| rs369965543 | 19:39,789,086 | C/T | — | uncertain significance |
| rs752011035 | 19:39,789,089 | G/A | — | uncertain significance |
| rs30461 | 19:39,789,115 | A/G | missense variant | — |
| rs150836308 | 19:39,789,119 | T/C | — | uncertain significance |
| rs2145018028 | 19:39,789,128 | G/A | — | uncertain significance |
| rs370981133 | 19:39,789,131 | C/T | — | uncertain significance |
| rs759067456 | 19:39,789,137 | C/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.