IFNLR1
interferon lambda receptor 1
Summary
The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Known Variants47 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs10903034 | 1:24,480,905 | C/T | regulatory region variant | — |
| rs10903035 | 1:24,481,940 | G/A | regulatory region variant | — |
| rs11249006 | 1:24,482,474 | G/A | 3 prime UTR variant | — |
| rs59631801 | 1:24,483,643 | A/G | — | benign |
| rs764742091 | 1:24,483,648 | C/T | — | uncertain significance |
| rs143712729 | 1:24,483,661 | C/T | — | uncertain significance |
| rs781433394 | 1:24,483,686 | C/T | — | uncertain significance |
| rs575575280 | 1:24,483,696 | G/A | — | uncertain significance |
| rs2523102183 | 1:24,483,704 | G/T | — | uncertain significance |
| rs935452669 | 1:24,484,000 | C/G | — | uncertain significance |
| rs1021721452 | 1:24,484,039 | C/G | — | uncertain significance |
| rs778755478 | 1:24,484,083 | G/A | — | uncertain significance |
| rs141659592 | 1:24,484,099 | C/G | — | likely benign |
| rs895467233 | 1:24,484,106 | G/C | — | uncertain significance |
| rs1325856247 | 1:24,484,149 | T/C | — | uncertain significance |
| rs116722436 | 1:24,484,195 | C/T | — | benign |
| rs74399859 | 1:24,484,220 | G/T | — | likely benign |
| rs570292636 | 1:24,484,237 | T/C | — | likely benign |
| rs763367931 | 1:24,484,254 | G/T | — | uncertain significance |
| rs766969987 | 1:24,484,258 | T/C | — | uncertain significance |
| rs773933736 | 1:24,484,285 | T/C | — | uncertain significance |
| rs201444954 | 1:24,484,365 | G/A | — | uncertain significance |
| rs200996459 | 1:24,485,549 | C/T | — | uncertain significance |
| rs1369998345 | 1:24,485,657 | A/T | — | uncertain significance |
| rs74060530 | 1:24,485,955 | G/T | — | benign |
| rs377756977 | 1:24,486,060 | C/T | — | uncertain significance |
| rs1644419033 | 1:24,486,083 | A/T | — | uncertain significance |
| rs1557642925 | 1:24,488,076 | G/T | — | uncertain significance |
| rs141989044 | 1:24,488,093 | C/G | — | uncertain significance |
| rs1644443953 | 1:24,488,096 | G/A | — | uncertain significance |
| rs148521759 | 1:24,488,131 | C/T | — | benign |
| rs2523170421 | 1:24,495,941 | C/A | — | uncertain significance |
| rs78627520 | 1:24,495,968 | C/A | — | benign |
| rs777122633 | 1:24,495,969 | G/A | — | uncertain significance |
| rs199653713 | 1:24,495,972 | C/T | — | likely benign |
| rs769288938 | 1:24,496,024 | T/C | — | uncertain significance |
| rs115773768 | 1:24,496,050 | G/A | — | benign |
| rs748586754 | 1:24,496,066 | C/T | — | likely benign |
| rs35682685 | 1:24,496,067 | G/A | — | benign |
| rs374140475 | 1:24,496,068 | C/T | — | uncertain significance |
| rs371145844 | 1:24,496,074 | C/T | — | uncertain significance |
| rs562243702 | 1:24,496,080 | C/T | — | uncertain significance |
| rs750327742 | 1:24,496,098 | G/A | — | likely benign |
| rs200988201 | 1:24,507,310 | C/T | — | likely benign |
| rs78312791 | 1:24,513,613 | C/G | — | — |
| rs139958347 | 1:24,513,723 | G/C | missense variant | — |
| rs763613375 | 1:24,513,746 | C/T | — | likely benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.