IL10RA

interleukin 10 receptor subunit alpha

Summary

The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]

Known Variants378 total

rsidPosition (GRCh37)AllelesClassClinVar
rs86755324111:117,856,768G/T—benign
rs18515963511:117,857,113C/T—likely benign
rs205798536811:117,857,118C/T—uncertain significance
rs88604770511:117,857,129T/C—uncertain significance
rs75586590111:117,857,154C/T—uncertain significance
rs5600803711:117,857,190C/G—uncertain significance
rs139005429211:117,857,195C/T—uncertain significance
rs98969480711:117,857,198G/C—uncertain significance
rs76817713511:117,857,199T/C—uncertain significance
rs205798680911:117,857,202T/A—uncertain significance
rs425230111:117,857,203G/C—likely benign
rs88604770611:117,857,207C/T—uncertain significance
rs127925914411:117,857,212G/A—likely benign
rs205798718311:117,857,219C/T—uncertain significance
rs145206680411:117,857,226T/C—uncertain significance
rs123036144811:117,857,227C/T—likely benign
rs74842839511:117,857,228C/T—uncertain significance
rs7576990511:117,857,229G/C—uncertain significance
rs124923397811:117,857,247A/C—uncertain significance
rs118231252211:117,857,255G/T—uncertain significance
rs20099297011:117,857,257T/C—conflicting classifications of pathogenicity
rs5572136311:117,857,259C/T—conflicting classifications of pathogenicity
rs37695648411:117,857,260G/A—conflicting classifications of pathogenicity
rs88604770711:117,857,262G/A—conflicting classifications of pathogenicity
rs88604770811:117,857,264C/T—conflicting classifications of pathogenicity
rs132445530911:117,857,266C/T—likely benign
rs94854572711:117,857,269C/T—likely benign
rs1089220211:117,857,338G/C—benign
rs54071225611:117,857,388C/T—likely benign
rs425224811:117,858,983G/A—benign
rs54625842011:117,859,081A/G—benign
rs20011545611:117,859,091C/T—likely benign
rs141419022111:117,859,096G/A—likely pathogenic
rs205800091211:117,859,100C/A—uncertain significance
rs56012858511:117,859,101A/C—conflicting classifications of pathogenicity
rs15014030311:117,859,104G/T—benign
rs75575877711:117,859,109C/T—uncertain significance
rs249677189011:117,859,110C/G—likely benign
rs77816824911:117,859,116T/C—likely benign
rs74962204411:117,859,118C/T—conflicting classifications of pathogenicity
rs74787240711:117,859,119G/A—likely benign
rs213498162711:117,859,122T/C—likely benign
rs37752575311:117,859,125G/A—conflicting classifications of pathogenicity
rs20017510611:117,859,143T/A—uncertain significance
rs213498167611:117,859,149C/T—likely benign
rs57083343511:117,859,155C/T—likely benign
rs159126100611:117,859,161C/T—likely benign
rs11231751111:117,859,165A/G—likely benign
rs76279292211:117,859,167A/G—likely benign
rs249677209011:117,859,169C/G—uncertain significance
rs14046654111:117,859,173C/T—likely benign
rs104104295211:117,859,179T/G—uncertain significance
rs136615260411:117,859,184C/G—uncertain significance
rs213498174511:117,859,187A/C—uncertain significance
rs77289993311:117,859,190G/C—uncertain significance
rs20164327711:117,859,199A/Gmissense variantpathogenic
rs57294513611:117,859,201G/A—likely benign
rs96579916511:117,859,206G/A—likely benign
rs425224911:117,859,209G/A—benign
rs425225011:117,859,210C/G—likely benign
rs144661442911:117,859,213C/A—uncertain significance
rs77262291611:117,859,216A/G—uncertain significance
rs78033442211:117,859,220G/A—uncertain significance
rs249677226611:117,859,231A/G—likely benign
rs57518451411:117,859,235G/A—likely benign
rs249677405011:117,860,145G/C—likely benign
rs120772002311:117,860,187C/T—likely benign
rs140905672611:117,860,205G/C—likely benign
rs13785358011:117,860,219C/Tmissense variantpathogenic
rs76366264411:117,860,220C/T—likely benign
rs14844109211:117,860,221G/A—uncertain significance
rs249677427811:117,860,230T/C—likely benign
rs133393461311:117,860,242C/T—uncertain significance
rs20217226611:117,860,250T/C—likely benign
rs249677437011:117,860,252G/T—uncertain significance
rs37433010111:117,860,257C/T—uncertain significance
rs75204340011:117,860,258G/A—uncertain significance
rs205800871211:117,860,268G/A—likely benign
rs36828771111:117,860,269C/Asynonymous variantuncertain significance
rs37237285111:117,860,270G/A—conflicting classifications of pathogenicity
rs94920162611:117,860,275G/C—uncertain significance
rs249677445611:117,860,278G/A—uncertain significance
rs3551106911:117,860,280C/T—benign
rs18837845011:117,860,281G/A—uncertain significance
rs55798550811:117,860,286C/T—likely benign
rs74700913211:117,860,287C/T—uncertain significance
rs14594971811:117,860,288G/A—conflicting classifications of pathogenicity
rs19274927411:117,860,304C/T—conflicting classifications of pathogenicity
rs425230311:117,860,305G/A—likely benign
rs75953744411:117,860,317C/T—pathogenic
rs205800952011:117,860,330A/T—uncertain significance
rs76810679911:117,860,339C/T—uncertain significance
rs249677466711:117,860,345C/T—likely benign
rs75616084211:117,860,347C/G—likely benign
rs75993944211:117,863,936C/T—likely benign
rs425230811:117,863,938C/G—likely benign
rs75389054411:117,863,940C/A—likely benign
rs75471390911:117,863,966A/T—likely benign
rs133910355011:117,863,989T/C—uncertain significance
rs15040178411:117,863,995A/G—uncertain significance

Showing 100 of 378 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.