IL15
interleukin 15
Summary
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq, Feb 2011]
Known Variants23 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs3806798 | 4:142,557,279 | T/A | regulatory region variant | — |
| rs12508866 | 4:142,565,693 | T/C | intron variant | — |
| rs1519551 | 4:142,570,472 | G/A | intron variant | — |
| rs13123506 | 4:142,623,030 | G/A | intron variant | — |
| rs62327424 | 4:142,623,499 | G/A | intron variant | — |
| rs6819823 | 4:142,638,751 | T/C | — | — |
| rs2254514 | 4:142,640,538 | T/C | 5 prime UTR variant | — |
| rs2857261 | 4:142,640,637 | A/G | splice region variant | — |
| rs768693821 | 4:142,641,631 | T/G | — | uncertain significance |
| rs200531127 | 4:142,643,115 | G/T | — | uncertain significance |
| rs753746979 | 4:142,649,115 | T/C | — | uncertain significance |
| rs779898572 | 4:142,649,128 | T/G | — | uncertain significance |
| rs769020860 | 4:142,649,135 | C/T | — | uncertain significance |
| rs116501276 | 4:142,651,108 | C/T | — | benign |
| rs2546294252 | 4:142,651,120 | A/C | — | uncertain significance |
| rs6537060 | 4:142,652,053 | G/A | regulatory region variant | — |
| rs1493024 | 4:142,652,387 | C/A | — | — |
| rs10519612 | 4:142,653,701 | A/T | — | — |
| rs145684493 | 4:142,653,920 | T/C | — | likely benign |
| rs373017717 | 4:142,653,942 | A/T | — | uncertain significance |
| rs1730493555 | 4:142,653,948 | G/C | — | uncertain significance |
| rs10519613 | 4:142,654,084 | C/A | 3 prime UTR variant | — |
| rs10833 | 4:142,654,547 | T/A | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.