IL15RA
interleukin 15 receptor subunit alpha
Summary
This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.[provided by RefSeq, Apr 2010]
Known Variants39 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs376752996 | 10:5,993,086 | C/T | — | — |
| rs2296135 | 10:5,994,694 | A/C | 3 prime UTR variant | — |
| rs41290325 | 10:5,995,112 | A/G | — | likely benign |
| rs141171117 | 10:5,995,147 | C/T | — | benign |
| rs147420996 | 10:5,995,158 | G/A | — | uncertain significance |
| rs774656798 | 10:5,995,162 | G/A | — | likely benign |
| rs759647467 | 10:5,998,369 | G/A | — | uncertain significance |
| rs1471039577 | 10:5,998,373 | C/T | — | uncertain significance |
| rs142602826 | 10:5,998,405 | G/A | — | uncertain significance |
| rs2228059 | 10:6,002,368 | T/G | missense variant | benign |
| rs150004304 | 10:6,002,400 | G/C | — | likely benign |
| rs1455727738 | 10:6,002,405 | A/G | — | likely benign |
| rs530970863 | 10:6,002,407 | T/C | — | uncertain significance |
| rs201871586 | 10:6,002,470 | G/A | — | uncertain significance |
| rs747770329 | 10:6,002,492 | C/T | — | uncertain significance |
| rs3136616 | 10:6,002,494 | G/A | — | likely benign |
| rs759778003 | 10:6,002,497 | G/A | — | uncertain significance |
| rs750678150 | 10:6,002,513 | G/A | — | likely benign |
| rs143591030 | 10:6,005,727 | T/C | — | uncertain significance |
| rs41294171 | 10:6,005,756 | G/A | — | benign |
| rs1318247441 | 10:6,005,778 | G/A | — | uncertain significance |
| rs8177688 | 10:6,007,549 | A/G | — | — |
| rs371140892 | 10:6,008,149 | G/A | — | uncertain significance |
| rs1333884900 | 10:6,008,153 | C/A | — | uncertain significance |
| rs2296139 | 10:6,008,172 | C/T | synonymous variant | — |
| rs8177683 | 10:6,008,958 | C/T | intron variant | — |
| rs146712466 | 10:6,011,769 | C/T | intron variant | — |
| rs8177653 | 10:6,015,381 | A/G | intron variant | — |
| rs8177652 | 10:6,015,384 | G/A | intron variant | — |
| rs8177651 | 10:6,015,390 | T/A | intron variant | — |
| rs7086174 | 10:6,016,399 | C/A | intron variant | — |
| rs8177643 | 10:6,016,620 | C/T | intron variant | — |
| rs8177641 | 10:6,016,892 | A/G | intron variant | — |
| rs894474179 | 10:6,019,397 | A/G | — | uncertain significance |
| rs1233719795 | 10:6,019,437 | G/A | — | uncertain significance |
| rs2539566263 | 10:6,019,448 | G/A | — | uncertain significance |
| rs8177763 | 10:6,019,546 | T/C | — | likely benign |
| rs8177761 | 10:6,020,866 | T/A | — | — |
| rs8177619 | 10:6,022,144 | C/G | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.