IL17RC

interleukin 17 receptor C

Summary

This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]

Known Variants598 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs200521188	3:9,957,033	C/A	missense variant	—
rs757463150	3:9,959,005	T/C	—	likely benign
rs144276462	3:9,959,011	C/G	—	benign
rs2470067254	3:9,959,013	G/C	—	uncertain significance
rs2125112075	3:9,959,019	T/C	—	uncertain significance
rs1559286070	3:9,959,020	G/A	—	likely benign
rs767780663	3:9,959,026	C/G	—	likely benign
rs7643547	3:9,959,033	C/T	—	benign
rs559955121	3:9,959,039	C/T	—	uncertain significance
rs112532783	3:9,959,040	G/A	—	uncertain significance
rs551367437	3:9,959,041	A/C	—	likely benign
rs2125112257	3:9,959,043	G/A	—	uncertain significance
rs1413047376	3:9,959,044	C/T	—	likely benign
rs2083164011	3:9,959,051	G/T	—	uncertain significance
rs1053229723	3:9,959,056	T/C	—	likely benign
rs2083165085	3:9,959,061	T/C	—	uncertain significance
rs2125112486	3:9,959,067	G/C	—	uncertain significance
rs1375505658	3:9,959,068	G/T	—	uncertain significance
rs2125112536	3:9,959,071	T/G	—	likely benign
rs2083166487	3:9,959,077	G/T	—	likely benign
rs456070	3:9,959,081	C/T	—	uncertain significance
rs753551976	3:9,959,086	C/T	—	likely benign
rs756868871	3:9,959,087	G/T	—	uncertain significance
rs778732124	3:9,959,092	C/T	—	likely benign
rs779864708	3:9,959,095	C/T	—	likely benign
rs1190758888	3:9,959,102	C/T	—	uncertain significance
rs746906866	3:9,959,103	C/T	—	uncertain significance
rs750455361	3:9,959,104	G/A	—	likely benign
rs748422918	3:9,959,105	G/A	—	uncertain significance
rs201879409	3:9,959,116	A/G	—	likely benign
rs2470069769	3:9,959,121	G/A	—	uncertain significance
rs763231993	3:9,959,122	G/A	—	uncertain significance
rs1029808780	3:9,959,123	G/A	—	uncertain significance
rs192927730	3:9,959,128	C/T	—	likely benign
rs1225874954	3:9,959,129	G/A	—	uncertain significance
rs2083174482	3:9,959,137	G/T	—	uncertain significance
rs760080059	3:9,959,148	A/G	—	uncertain significance
rs2470070931	3:9,959,155	G/T	—	uncertain significance
rs2470070978	3:9,959,156	G/C	—	uncertain significance
rs139130574	3:9,959,160	A/G	—	uncertain significance
rs75116348	3:9,959,166	G/A	—	likely benign
rs1470023019	3:9,959,167	C/A	—	uncertain significance
rs2083177870	3:9,959,168	C/T	—	uncertain significance
rs1187065150	3:9,959,172	G/T	—	uncertain significance
rs1412304817	3:9,959,188	T/C	—	likely benign
rs2470072063	3:9,959,192	G/A	—	uncertain significance
rs2125114097	3:9,959,197	T/C	—	likely benign
rs2470072232	3:9,959,198	G/T	—	uncertain significance
rs758141242	3:9,959,199	C/T	—	uncertain significance
rs779886588	3:9,959,206	T/C	—	likely benign
rs754915462	3:9,959,214	C/G	—	uncertain significance
rs2470073041	3:9,959,219	C/T	—	likely benign
rs1273968107	3:9,959,223	C/G	—	uncertain significance
rs769926895	3:9,959,228	G/A	—	uncertain significance
rs865832079	3:9,959,229	C/T	—	uncertain significance
rs369075354	3:9,959,233	T/C	—	likely benign
rs771263643	3:9,959,235	G/A	—	uncertain significance
rs553003266	3:9,959,249	C/T	—	conflicting classifications of pathogenicity
rs760007478	3:9,959,250	G/A	—	uncertain significance
rs1378358931	3:9,959,253	G/A	—	uncertain significance
rs964528502	3:9,959,282	C/T	—	likely benign
rs781279005	3:9,959,288	G/C	—	uncertain significance
rs752623690	3:9,959,289	G/T	—	uncertain significance
rs1246384208	3:9,959,293	T/G	—	likely benign
rs755594301	3:9,959,301	C/T	—	uncertain significance
rs147897013	3:9,959,302	G/A	—	likely benign
rs778955786	3:9,959,305	G/A	—	likely benign
rs746277421	3:9,959,306	C/G	—	uncertain significance
rs772360458	3:9,959,312	A/G	—	uncertain significance
rs775994750	3:9,959,314	A/G	—	likely benign
rs2470077192	3:9,959,331	T/G	—	likely benign
rs2470078647	3:9,959,383	T/G	—	likely benign
rs2125117518	3:9,959,392	C/G	—	likely benign
rs756084638	3:9,959,393	C/T	—	likely benign
rs753971413	3:9,959,407	G/C	—	uncertain significance
rs757246461	3:9,959,409	C/G	—	uncertain significance
rs75324888	3:9,959,410	G/A	—	benign
rs374603469	3:9,959,417	G/C	—	uncertain significance
rs2125117879	3:9,959,419	G/A	—	uncertain significance
rs1397218746	3:9,959,424	T/C	—	uncertain significance
rs1393246582	3:9,959,426	T/G	—	likely benign
rs2470080216	3:9,959,433	T/C	—	likely benign
rs199651841	3:9,959,591	G/A	—	likely benign
rs2083233993	3:9,959,594	C/A	—	likely benign
rs775241631	3:9,959,597	C/G	—	uncertain significance
rs2083235342	3:9,959,600	C/T	—	likely benign
rs2083236031	3:9,959,605	A/C	—	uncertain significance
rs988744665	3:9,959,613	A/T	—	uncertain significance
rs2125120917	3:9,959,620	C/G	—	likely benign
rs2083237428	3:9,959,626	G/A	—	likely benign
rs2470086881	3:9,959,630	G/A	—	uncertain significance
rs148170215	3:9,959,632	G/A	—	benign
rs2470087054	3:9,959,636	A/G	—	uncertain significance
rs761652113	3:9,959,637	T/A	—	uncertain significance
rs765402459	3:9,959,638	C/T	—	likely benign
rs750484094	3:9,959,639	G/A	—	conflicting classifications of pathogenicity
rs138985119	3:9,959,640	T/C	—	likely benign
rs1475549372	3:9,959,649	C/T	—	conflicting classifications of pathogenicity
rs146222177	3:9,959,650	G/A	—	likely benign
rs753283137	3:9,959,654	C/T	—	uncertain significance

Showing 100 of 598 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.