IL1R2
interleukin 1 receptor type 2
Summary
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012]
Known Variants48 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs77278138 | 2:102,606,595 | G/A | upstream gene variant | — |
| rs11886877 | 2:102,610,721 | G/T | — | — |
| rs11674595 | 2:102,610,992 | T/C | intron variant | — |
| rs4321386 | 2:102,613,013 | C/G | intron variant | — |
| rs151100901 | 2:102,615,277 | C/A | regulatory region variant | — |
| rs2071008 | 2:102,615,279 | T/A | — | — |
| rs13388734 | 2:102,615,336 | G/A | regulatory region variant | — |
| rs7561191 | 2:102,616,978 | T/A | intron variant | — |
| rs7570441 | 2:102,616,995 | G/A | intron variant | — |
| rs7561460 | 2:102,617,204 | T/C | intron variant | — |
| rs17026377 | 2:102,617,287 | C/T | intron variant | — |
| rs4851526 | 2:102,618,370 | A/G | regulatory region variant | — |
| rs4851527 | 2:102,622,376 | A/G | intron variant | — |
| rs719250 | 2:102,623,718 | C/T | intron variant | — |
| rs2302589 | 2:102,624,786 | C/T | intron variant | — |
| rs200366216 | 2:102,624,994 | C/A | — | likely benign |
| rs148522700 | 2:102,625,053 | G/A | — | likely benign |
| rs769041254 | 2:102,625,102 | C/G | — | uncertain significance |
| rs2236930 | 2:102,625,880 | T/C | — | — |
| rs149708591 | 2:102,626,054 | G/A | — | likely benign |
| rs1400902808 | 2:102,626,135 | C/T | — | uncertain significance |
| rs28362312 | 2:102,626,142 | C/G | — | likely benign |
| rs143906708 | 2:102,626,208 | A/G | — | benign |
| rs375271905 | 2:102,626,219 | C/A | — | uncertain significance |
| rs760435724 | 2:102,626,227 | G/A | — | uncertain significance |
| rs142963191 | 2:102,626,274 | C/T | — | likely benign |
| rs565655684 | 2:102,631,176 | T/C | — | — |
| rs746839384 | 2:102,632,359 | C/G | — | uncertain significance |
| rs148689791 | 2:102,632,401 | C/T | — | uncertain significance |
| rs144052963 | 2:102,632,416 | C/T | — | uncertain significance |
| rs143112573 | 2:102,632,479 | G/A | — | uncertain significance |
| rs28385682 | 2:102,636,127 | G/A | — | benign |
| rs764905517 | 2:102,636,202 | C/T | — | uncertain significance |
| rs1285373959 | 2:102,636,223 | C/T | — | uncertain significance |
| rs2072476 | 2:102,636,864 | C/T | intron variant | — |
| rs3218961 | 2:102,638,645 | T/G | — | likely benign |
| rs183091210 | 2:102,638,698 | A/G | — | uncertain significance |
| rs539163580 | 2:102,639,762 | T/C | — | — |
| rs780167021 | 2:102,641,022 | T/G | — | uncertain significance |
| rs370345051 | 2:102,641,089 | G/A | — | likely benign |
| rs374536258 | 2:102,641,109 | G/A | — | uncertain significance |
| rs776757109 | 2:102,641,126 | C/T | — | uncertain significance |
| rs929117282 | 2:102,642,679 | C/A | — | uncertain significance |
| rs2072472 | 2:102,643,019 | A/G | intron variant | — |
| rs181563229 | 2:102,644,744 | G/A | — | uncertain significance |
| rs776422051 | 2:102,644,772 | G/A | — | uncertain significance |
| rs138160797 | 2:102,644,801 | G/C | — | uncertain significance |
| rs1052308003 | 2:102,644,820 | C/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.