IL22RA2
interleukin 22 receptor subunit alpha 2
Summary
This gene encodes a member of the class II cytokine receptor family. The encoded soluble protein specifically binds to and inhibits interleukin 22 activity by blocking the interaction of interleukin 22 with its cell surface receptor. The encoded protein may be important in the regulation of inflammatory response, and has been implicated in the regulation of tumorigenesis in the colon. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]
Known Variants19 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs372536538 | 6:137,466,778 | A/G | — | uncertain significance |
| rs1778163784 | 6:137,466,816 | G/A | — | uncertain significance |
| rs142863060 | 6:137,466,819 | T/C | — | uncertain significance |
| rs1165831693 | 6:137,466,856 | G/A | — | uncertain significance |
| rs377061506 | 6:137,466,870 | A/G | — | uncertain significance |
| rs768824042 | 6:137,466,877 | C/A | — | uncertain significance |
| rs761897135 | 6:137,466,879 | G/A | — | likely benign |
| rs1179817502 | 6:137,476,080 | T/G | — | uncertain significance |
| rs372221321 | 6:137,476,098 | C/T | — | uncertain significance |
| rs745893397 | 6:137,476,101 | G/A | — | uncertain significance |
| rs141572567 | 6:137,476,140 | G/A | — | uncertain significance |
| rs150492179 | 6:137,476,153 | C/T | — | uncertain significance |
| rs2064501 | 6:137,477,823 | C/G | — | — |
| rs772229715 | 6:137,479,523 | A/T | — | uncertain significance |
| rs754351808 | 6:137,479,565 | C/T | — | uncertain significance |
| rs201560036 | 6:137,479,566 | G/A | — | risk factor |
| rs2548211372 | 6:137,479,574 | A/T | — | uncertain significance |
| rs77622675 | 6:137,479,604 | T/C | — | uncertain significance |
| rs28385692 | 6:137,482,840 | A/G | missense variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.