IL25
interleukin 25
Summary
The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this cytokine may be a pro-inflammatory cytokine favoring the Th2-type immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Known Variants19 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs10137082 | 14:23,840,033 | C/G | — | — |
| rs1566496988 | 14:23,842,419 | A/C | — | uncertain significance |
| rs769906314 | 14:23,842,430 | C/T | — | uncertain significance |
| rs762878140 | 14:23,842,440 | G/A | — | uncertain significance |
| rs765453544 | 14:23,842,496 | G/C | — | uncertain significance |
| rs747167983 | 14:23,842,545 | C/A | — | uncertain significance |
| rs2502099965 | 14:23,844,844 | G/T | — | uncertain significance |
| rs747685813 | 14:23,844,868 | C/G | — | uncertain significance |
| rs774468698 | 14:23,844,880 | C/T | — | uncertain significance |
| rs914496697 | 14:23,844,952 | C/G | — | uncertain significance |
| rs1124053 | 14:23,844,979 | C/T | missense variant | benign |
| rs1359119715 | 14:23,844,985 | C/G | — | uncertain significance |
| rs746436829 | 14:23,844,997 | G/A | — | likely benign |
| rs776839088 | 14:23,845,013 | A/G | — | uncertain significance |
| rs1463684200 | 14:23,845,031 | G/T | — | uncertain significance |
| rs375340039 | 14:23,845,043 | G/A | — | uncertain significance |
| rs149802556 | 14:23,845,061 | T/C | — | uncertain significance |
| rs145694193 | 14:23,845,070 | G/A | — | uncertain significance |
| rs148309201 | 14:23,845,076 | G/A | — | likely benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.