IL27RA
interleukin 27 receptor subunit alpha
Summary
In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein. [provided by RefSeq, Jul 2008]
Known Variants51 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1466759141 | 19:14,142,701 | G/C | — | likely benign |
| rs761504616 | 19:14,142,707 | C/G | — | uncertain significance |
| rs1975821082 | 19:14,142,724 | C/A | — | uncertain significance |
| rs1446802450 | 19:14,142,760 | C/G | — | uncertain significance |
| rs2512519213 | 19:14,143,207 | G/T | — | uncertain significance |
| rs759392469 | 19:14,143,239 | G/A | — | uncertain significance |
| rs774377074 | 19:14,150,357 | G/A | — | uncertain significance |
| rs2512523795 | 19:14,150,370 | T/C | — | uncertain significance |
| rs2512523817 | 19:14,150,389 | G/C | — | uncertain significance |
| rs2512523818 | 19:14,150,390 | C/T | — | likely benign |
| rs758946711 | 19:14,150,427 | A/G | — | uncertain significance |
| rs368706518 | 19:14,150,438 | C/T | — | uncertain significance |
| rs1231833843 | 19:14,150,443 | C/G | — | likely benign |
| rs375264330 | 19:14,150,459 | G/A | — | uncertain significance |
| rs776854880 | 19:14,150,470 | A/C | — | uncertain significance |
| rs376709516 | 19:14,150,589 | G/T | — | uncertain significance |
| rs758208255 | 19:14,150,625 | A/T | — | uncertain significance |
| rs113485753 | 19:14,153,272 | C/T | — | benign |
| rs1599300152 | 19:14,153,303 | T/G | — | likely benign |
| rs768013483 | 19:14,153,355 | C/T | — | uncertain significance |
| rs772990308 | 19:14,153,385 | G/A | — | uncertain significance |
| rs147347872 | 19:14,153,416 | C/T | — | likely benign |
| rs1976010706 | 19:14,153,561 | G/C | — | uncertain significance |
| rs201300850 | 19:14,157,021 | G/A | — | uncertain significance |
| rs755899251 | 19:14,157,025 | G/T | — | uncertain significance |
| rs1314390811 | 19:14,157,059 | C/G | — | uncertain significance |
| rs958764923 | 19:14,157,104 | G/A | — | uncertain significance |
| rs113191093 | 19:14,157,158 | C/G | — | benign |
| rs758312923 | 19:14,157,257 | C/G | — | uncertain significance |
| rs760050077 | 19:14,157,290 | G/C | — | uncertain significance |
| rs139761127 | 19:14,157,293 | C/T | — | uncertain significance |
| rs746068714 | 19:14,157,317 | C/T | — | uncertain significance |
| rs143621300 | 19:14,157,326 | G/C | — | uncertain significance |
| rs149202847 | 19:14,157,331 | C/T | — | conflicting classifications of pathogenicity |
| rs10422837 | 19:14,158,152 | A/G | regulatory region variant | — |
| rs76209808 | 19:14,159,806 | C/T | — | benign |
| rs768423793 | 19:14,159,820 | G/A | — | uncertain significance |
| rs200162447 | 19:14,159,856 | C/T | — | likely benign |
| rs761131213 | 19:14,160,066 | C/T | — | uncertain significance |
| rs200364222 | 19:14,160,076 | A/G | — | uncertain significance |
| rs200391665 | 19:14,161,608 | C/T | — | uncertain significance |
| rs753801958 | 19:14,161,674 | A/G | — | uncertain significance |
| rs994827825 | 19:14,161,681 | G/C | — | uncertain significance |
| rs749840218 | 19:14,162,430 | A/G | — | uncertain significance |
| rs201844321 | 19:14,162,505 | T/A | — | uncertain significance |
| rs148749814 | 19:14,162,740 | A/G | — | benign |
| rs954034181 | 19:14,162,780 | A/G | — | uncertain significance |
| rs763416001 | 19:14,162,953 | G/A | — | uncertain significance |
| rs139468413 | 19:14,162,972 | C/A | — | uncertain significance |
| rs376141649 | 19:14,163,010 | G/A | — | uncertain significance |
| rs201507486 | 19:14,163,014 | C/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.