IL31RA
interleukin 31 receptor A
Summary
The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
Known Variants58 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs371900126 | 5:55,147,431 | G/C | — | likely benign |
| rs140079651 | 5:55,147,452 | A/G | — | likely benign |
| rs1169339313 | 5:55,147,457 | A/G | — | uncertain significance |
| rs190185736 | 5:55,149,383 | C/T | — | likely benign |
| rs757119386 | 5:55,155,388 | C/G | — | uncertain significance |
| rs1009639 | 5:55,155,402 | T/C | — | benign |
| rs140536651 | 5:55,155,404 | C/T | — | benign |
| rs753593195 | 5:55,164,700 | A/G | — | uncertain significance |
| rs59086632 | 5:55,168,132 | A/G | — | benign |
| rs1262185080 | 5:55,168,226 | A/T | — | uncertain significance |
| rs143542336 | 5:55,168,252 | A/G | — | uncertain significance |
| rs148785939 | 5:55,168,257 | A/G | — | benign |
| rs2533162903 | 5:55,178,964 | C/T | — | uncertain significance |
| rs768629615 | 5:55,178,991 | C/T | — | uncertain significance |
| rs183184063 | 5:55,179,033 | G/T | — | likely benign |
| rs10940491 | 5:55,179,052 | A/T | — | benign |
| rs184629498 | 5:55,180,365 | C/T | intron variant | — |
| rs146511172 | 5:55,185,899 | G/A | — | benign |
| rs144829917 | 5:55,185,900 | G/A | — | conflicting classifications of pathogenicity |
| rs2533203999 | 5:55,185,926 | C/A | — | uncertain significance |
| rs73118479 | 5:55,192,169 | T/C | — | benign |
| rs544735425 | 5:55,192,209 | G/A | — | likely benign |
| rs371988926 | 5:55,192,223 | C/A | — | uncertain significance |
| rs141877896 | 5:55,192,224 | G/A | — | likely benign |
| rs1376822500 | 5:55,192,235 | G/A | — | uncertain significance |
| rs138848554 | 5:55,195,008 | A/G | intron variant | — |
| rs2533294656 | 5:55,201,938 | T/G | — | uncertain significance |
| rs771928755 | 5:55,202,020 | A/T | — | uncertain significance |
| rs763666434 | 5:55,202,025 | G/C | — | uncertain significance |
| rs2533295582 | 5:55,202,038 | T/C | — | uncertain significance |
| rs747532999 | 5:55,202,096 | C/T | — | uncertain significance |
| rs369809822 | 5:55,202,097 | G/C | — | likely benign |
| rs375568629 | 5:55,203,261 | T/A | — | uncertain significance |
| rs1303913358 | 5:55,204,139 | G/T | — | uncertain significance |
| rs2533307473 | 5:55,204,155 | T/G | — | uncertain significance |
| rs9632389 | 5:55,204,187 | G/T | — | benign |
| rs74629680 | 5:55,204,318 | C/T | — | benign |
| rs1561123720 | 5:55,206,411 | G/A | — | uncertain significance |
| rs1561123748 | 5:55,206,420 | C/T | — | pathogenic |
| rs161704 | 5:55,206,444 | A/G | — | benign |
| rs2533321633 | 5:55,206,459 | G/A | — | uncertain significance |
| rs760650621 | 5:55,209,355 | A/C | — | uncertain significance |
| rs752948148 | 5:55,210,681 | G/T | — | uncertain significance |
| rs17701253 | 5:55,210,702 | T/C | — | benign |
| rs16884641 | 5:55,212,446 | T/G | — | benign |
| rs769172419 | 5:55,212,592 | G/A | — | uncertain significance |
| rs2533349293 | 5:55,212,593 | T/C | — | uncertain significance |
| rs116001952 | 5:55,212,601 | G/A | — | likely benign |
| rs148721785 | 5:55,212,667 | G/C | — | benign |
| rs539031810 | 5:55,212,706 | A/G | — | uncertain significance |
| rs764336987 | 5:55,212,760 | C/A | — | uncertain significance |
| rs1032889596 | 5:55,212,763 | C/T | — | likely benign |
| rs763337032 | 5:55,212,767 | C/G | — | uncertain significance |
| rs748001461 | 5:55,212,787 | C/T | — | likely benign |
| rs541834884 | 5:55,212,788 | G/A | — | uncertain significance |
| rs141946255 | 5:55,212,796 | G/A | — | uncertain significance |
| rs746001636 | 5:55,212,811 | C/T | — | uncertain significance |
| rs752700330 | 5:55,212,922 | C/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.