IL36RN

interleukin 36 receptor antagonist

Summary

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

Known Variants169 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs759570472	2:113,816,671	G/A	—	uncertain significance
rs552166255	2:113,816,690	G/C	—	uncertain significance
rs886054765	2:113,816,799	G/A	—	uncertain significance
rs1440056356	2:113,816,819	G/A	—	uncertain significance
rs2278716	2:113,816,940	C/G	—	benign
rs2278717	2:113,816,942	A/C	—	benign
rs28938771	2:113,817,021	C/T	—	conflicting classifications of pathogenicity
rs766403906	2:113,817,023	T/C	—	uncertain significance
rs767435510	2:113,817,032	C/T	—	uncertain significance
rs577280688	2:113,817,033	G/A	—	likely benign
rs397514630	2:113,817,043	C/T	stop gained	pathogenic
rs752880718	2:113,817,044	G/A	—	uncertain significance
rs1489262806	2:113,817,045	G/A	—	likely pathogenic
rs976893250	2:113,817,047	G/A	—	uncertain significance
rs1685595922	2:113,817,049	G/A	—	uncertain significance
rs1685595982	2:113,817,050	T/C	—	uncertain significance
rs1553463979	2:113,817,051	G/A	—	likely benign
rs1476532102	2:113,817,059	C/G	—	likely benign
rs2515392	2:113,817,181	C/T	—	benign
rs7575934	2:113,817,334	C/T	intron variant	—
rs1530552	2:113,818,120	G/C	—	—
rs1685626921	2:113,818,411	C/A	—	likely benign
rs886054766	2:113,818,415	T/A	—	uncertain significance
rs760855986	2:113,818,416	C/T	—	likely benign
rs764444805	2:113,818,417	C/T	—	likely benign
rs2466802788	2:113,818,427	A/G	—	likely pathogenic
rs1685627126	2:113,818,428	G/T	—	likely pathogenic
rs1191516439	2:113,818,439	T/G	—	uncertain significance
rs200623658	2:113,818,441	G/A	—	likely benign
rs1348538791	2:113,818,474	G/A	—	likely benign
rs387906914	2:113,818,479	T/C	missense variant	pathogenic
rs777423707	2:113,818,490	C/A	—	uncertain significance
rs2466803136	2:113,818,496	G/A	—	uncertain significance
rs1573386377	2:113,818,500	G/C	—	uncertain significance
rs941319736	2:113,818,501	G/A	—	likely benign
rs187015338	2:113,818,503	A/G	missense variant	pathogenic
rs2105068105	2:113,818,518	G/A	—	uncertain significance
rs772037773	2:113,818,519	G/A	—	uncertain significance
rs148755083	2:113,818,520	T/C	splice region variant	pathogenic
rs760803052	2:113,818,521	G/A	—	likely benign
rs764097178	2:113,818,523	T/C	—	likely benign
rs2466803230	2:113,818,528	C/T	—	likely benign
rs200453384	2:113,818,529	A/G	—	likely benign
rs2251872	2:113,818,632	G/A	—	benign
rs2252007	2:113,819,614	T/C	—	benign
rs2466805446	2:113,819,690	C/T	—	likely benign
rs2466805457	2:113,819,695	C/T	—	likely benign
rs2105069232	2:113,819,696	C/G	—	likely benign
rs1685653783	2:113,819,708	G/T	—	uncertain significance
rs776622427	2:113,819,715	G/A	—	uncertain significance
rs145099228	2:113,819,721	C/T	—	uncertain significance
rs1685654399	2:113,819,724	A/G	—	uncertain significance
rs28938777	2:113,819,725	A/T	—	uncertain significance
rs151325121	2:113,819,727	C/T	missense variant	pathogenic
rs1196401590	2:113,819,729	G/C	—	likely benign
rs1300922765	2:113,819,733	C/T	—	likely benign
rs1458580125	2:113,819,749	C/T	—	uncertain significance
rs2105069324	2:113,819,750	C/A	—	likely benign
rs549588385	2:113,819,753	C/T	—	likely benign
rs77864207	2:113,819,754	G/A	—	conflicting classifications of pathogenicity
rs2466805738	2:113,819,769	C/T	—	pathogenic
rs746941547	2:113,819,773	G/T	—	uncertain significance
rs781328070	2:113,819,779	G/A	—	uncertain significance
rs1265230096	2:113,819,785	G/T	—	uncertain significance
rs375718709	2:113,819,793	T/C	—	uncertain significance
rs906488008	2:113,819,795	T/C	—	likely benign
rs1573387399	2:113,819,800	T/G	—	uncertain significance
rs139497891	2:113,819,812	C/T	—	conflicting classifications of pathogenicity
rs774906497	2:113,819,813	G/A	—	likely benign
rs372880215	2:113,819,815	C/T	—	uncertain significance
rs148271084	2:113,819,825	A/G	—	likely benign
rs2105069464	2:113,819,844	T/C	—	likely benign
rs1403502153	2:113,820,013	C/T	—	likely benign
rs749973247	2:113,820,015	C/T	—	likely benign
rs762586699	2:113,820,017	C/T	—	likely benign
rs1336671324	2:113,820,020	C/A	—	likely benign
rs374849220	2:113,820,024	C/T	—	conflicting classifications of pathogenicity
rs754661425	2:113,820,025	G/A	—	uncertain significance
rs144182857	2:113,820,031	C/T	—	conflicting classifications of pathogenicity
rs886054767	2:113,820,034	T/A	—	uncertain significance
rs2105069719	2:113,820,039	A/G	—	uncertain significance
rs1213179423	2:113,820,052	A/G	—	uncertain significance
rs1685662918	2:113,820,061	C/T	—	uncertain significance
rs746109701	2:113,820,063	A/G	—	uncertain significance
rs2466806970	2:113,820,068	A/G	—	likely benign
rs1573387667	2:113,820,077	C/A	—	uncertain significance
rs769214649	2:113,820,088	A/T	—	uncertain significance
rs199932303	2:113,820,090	C/T	missense variant	uncertain significance
rs371819085	2:113,820,091	G/A	—	uncertain significance
rs143557954	2:113,820,092	G/A	—	likely benign
rs375207169	2:113,820,093	C/T	—	uncertain significance
rs542606182	2:113,820,094	G/A	—	uncertain significance
rs1257617143	2:113,820,099	A/G	—	uncertain significance
rs144420774	2:113,820,103	G/C	—	uncertain significance
rs1573387732	2:113,820,108	A/T	—	uncertain significance
rs199824136	2:113,820,119	C/T	—	conflicting classifications of pathogenicity
rs143724424	2:113,820,120	G/A	—	uncertain significance
rs144478519	2:113,820,124	C/A	stop gained	pathogenic
rs1383851199	2:113,820,134	C/T	—	likely benign
rs780273771	2:113,820,135	C/G	—	uncertain significance

Showing 100 of 169 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.