INSC
INSC spindle orientation adaptor protein
Summary
In Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion mother cell on the basal side. Cell polarization is precisely regulated by 2 apically localized multiprotein signaling complexes that are tethered by Inscuteable, which regulates their apical localization (Izaki et al., 2006 [PubMed 16458856]).[supplied by OMIM, Mar 2008]
Known Variants49 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs200115207 | 11:15,134,023 | G/A | — | uncertain significance |
| rs2494010212 | 11:15,170,758 | T/A | — | uncertain significance |
| rs778432247 | 11:15,197,346 | C/A | — | uncertain significance |
| rs780511581 | 11:15,197,348 | G/A | — | uncertain significance |
| rs1403319921 | 11:15,197,381 | C/T | — | uncertain significance |
| rs201704069 | 11:15,197,442 | G/T | — | uncertain significance |
| rs750085808 | 11:15,197,446 | C/A | — | uncertain significance |
| rs766025835 | 11:15,197,525 | C/T | — | uncertain significance |
| rs141502743 | 11:15,197,534 | C/T | — | uncertain significance |
| rs374140597 | 11:15,197,556 | G/A | — | uncertain significance |
| rs200762851 | 11:15,197,573 | C/T | — | uncertain significance |
| rs2494126944 | 11:15,197,577 | C/T | — | uncertain significance |
| rs748096504 | 11:15,197,588 | G/A | — | uncertain significance |
| rs762481750 | 11:15,197,598 | C/G | — | uncertain significance |
| rs370303251 | 11:15,199,891 | G/T | — | uncertain significance |
| rs1348527627 | 11:15,212,264 | T/G | — | uncertain significance |
| rs763681856 | 11:15,212,330 | G/C | — | uncertain significance |
| rs11825533 | 11:15,216,556 | G/A | regulatory region variant | — |
| rs61745926 | 11:15,222,382 | G/A | — | benign |
| rs375629663 | 11:15,222,412 | A/T | — | uncertain significance |
| rs761410512 | 11:15,222,419 | G/A | — | uncertain significance |
| rs752669097 | 11:15,222,435 | G/C | — | uncertain significance |
| rs372620711 | 11:15,222,436 | G/A | — | uncertain significance |
| rs370920337 | 11:15,222,446 | C/T | — | uncertain significance |
| rs200555865 | 11:15,222,457 | A/C | — | uncertain significance |
| rs201865257 | 11:15,222,466 | G/A | — | uncertain significance |
| rs367596666 | 11:15,243,032 | G/A | — | uncertain significance |
| rs190828164 | 11:15,243,096 | C/T | — | uncertain significance |
| rs766623706 | 11:15,243,107 | G/A | — | uncertain significance |
| rs760508602 | 11:15,243,114 | T/C | — | uncertain significance |
| rs763983509 | 11:15,243,116 | A/C | — | uncertain significance |
| rs753837396 | 11:15,243,119 | T/C | — | uncertain significance |
| rs758029102 | 11:15,243,127 | C/A | — | uncertain significance |
| rs2494327669 | 11:15,243,170 | G/A | — | uncertain significance |
| rs376176241 | 11:15,247,297 | C/A | — | uncertain significance |
| rs61748861 | 11:15,247,307 | C/A | — | likely benign |
| rs185956954 | 11:15,247,308 | C/A | — | likely benign |
| rs61748860 | 11:15,247,310 | T/G | — | likely benign |
| rs747142793 | 11:15,247,357 | C/A | — | uncertain significance |
| rs7123855 | 11:15,260,471 | A/G | — | uncertain significance |
| rs1478152949 | 11:15,260,546 | A/C | — | uncertain significance |
| rs558991597 | 11:15,260,564 | C/A | — | uncertain significance |
| rs368344814 | 11:15,260,611 | C/T | — | uncertain significance |
| rs200582479 | 11:15,261,991 | A/G | splice region variant | — |
| rs949505051 | 11:15,261,993 | G/T | — | uncertain significance |
| rs576026524 | 11:15,262,052 | G/A | — | uncertain significance |
| rs199686458 | 11:15,267,467 | C/T | — | uncertain significance |
| rs777786881 | 11:15,267,468 | G/A | — | uncertain significance |
| rs371233254 | 11:15,267,533 | C/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.