INTS1
integrator complex subunit 1
Summary
INTS1 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Known Variants424 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs769280475 | 7:1,510,218 | T/G | — | uncertain significance |
| rs1781410732 | 7:1,510,224 | C/G | — | uncertain significance |
| rs763399857 | 7:1,510,230 | T/C | — | uncertain significance |
| rs370940992 | 7:1,510,263 | C/T | — | uncertain significance |
| rs777827501 | 7:1,510,281 | C/T | — | uncertain significance |
| rs780849947 | 7:1,510,287 | T/C | — | uncertain significance |
| rs767857574 | 7:1,510,322 | G/A | — | uncertain significance |
| rs1185744208 | 7:1,510,323 | C/T | — | uncertain significance |
| rs761770199 | 7:1,510,485 | G/C | — | uncertain significance |
| rs920564883 | 7:1,510,494 | G/C | — | uncertain significance |
| rs755849785 | 7:1,510,510 | G/T | — | uncertain significance |
| rs377062473 | 7:1,510,523 | G/A | — | uncertain significance |
| rs1432925039 | 7:1,510,558 | G/C | — | pathogenic |
| rs753542479 | 7:1,510,567 | C/T | — | likely benign |
| rs894183649 | 7:1,510,796 | G/A | — | uncertain significance |
| rs537368704 | 7:1,510,809 | C/T | — | uncertain significance |
| rs1036875282 | 7:1,510,820 | C/A | — | uncertain significance |
| rs73267806 | 7:1,510,831 | G/A | — | benign |
| rs149670463 | 7:1,510,834 | C/T | — | likely benign |
| rs541180800 | 7:1,510,848 | G/A | — | uncertain significance |
| rs376165628 | 7:1,510,854 | G/A | — | likely benign |
| rs370540456 | 7:1,510,865 | C/G | — | uncertain significance |
| rs751303536 | 7:1,510,866 | C/T | — | uncertain significance |
| rs117597074 | 7:1,511,201 | G/A | — | likely benign |
| rs201675191 | 7:1,511,214 | A/C | — | conflicting classifications of pathogenicity |
| rs200312224 | 7:1,511,236 | G/A | — | uncertain significance |
| rs201387183 | 7:1,511,239 | G/A | — | uncertain significance |
| rs777788844 | 7:1,511,248 | C/T | — | uncertain significance |
| rs774301668 | 7:1,511,271 | A/G | — | uncertain significance |
| rs73267808 | 7:1,511,273 | C/T | — | benign |
| rs112658175 | 7:1,511,943 | G/A | — | benign |
| rs199728337 | 7:1,511,954 | T/C | — | conflicting classifications of pathogenicity |
| rs763454561 | 7:1,511,957 | C/T | — | uncertain significance |
| rs752619551 | 7:1,511,974 | G/C | — | uncertain significance |
| rs200867969 | 7:1,511,987 | C/T | — | uncertain significance |
| rs780692540 | 7:1,511,992 | A/C | — | uncertain significance |
| rs1329147811 | 7:1,512,020 | C/T | — | uncertain significance |
| rs201873966 | 7:1,512,720 | C/T | — | likely benign |
| rs755943358 | 7:1,512,731 | C/T | — | likely benign |
| rs753547907 | 7:1,512,733 | G/C | — | uncertain significance |
| rs754444430 | 7:1,512,735 | C/G | — | uncertain significance |
| rs138397380 | 7:1,512,808 | G/C | — | conflicting classifications of pathogenicity |
| rs533859826 | 7:1,512,819 | C/T | — | uncertain significance |
| rs148225984 | 7:1,513,207 | C/T | — | likely benign |
| rs530171192 | 7:1,513,212 | C/T | — | uncertain significance |
| rs377759797 | 7:1,513,216 | G/A | — | likely benign |
| rs11774 | 7:1,513,227 | G/A | — | benign |
| rs1781575915 | 7:1,513,245 | G/C | — | likely benign |
| rs750907722 | 7:1,513,260 | T/G | — | uncertain significance |
| rs778930510 | 7:1,513,274 | A/C | — | uncertain significance |
| rs1284335313 | 7:1,513,278 | G/A | — | pathogenic |
| rs774170014 | 7:1,513,311 | G/A | — | uncertain significance |
| rs751820201 | 7:1,513,819 | G/C | — | uncertain significance |
| rs914393582 | 7:1,513,844 | G/A | — | uncertain significance |
| rs746675569 | 7:1,513,857 | C/T | — | uncertain significance |
| rs377362241 | 7:1,513,874 | G/A | — | uncertain significance |
| rs188391513 | 7:1,513,966 | G/A | — | benign |
| rs574453727 | 7:1,513,978 | C/T | — | likely benign |
| rs768241069 | 7:1,513,981 | G/C | — | uncertain significance |
| rs781097369 | 7:1,513,985 | A/G | — | uncertain significance |
| rs1200059911 | 7:1,513,986 | T/C | — | uncertain significance |
| rs1162809128 | 7:1,514,356 | G/A | — | pathogenic |
| rs374803757 | 7:1,514,378 | G/A | — | uncertain significance |
| rs2128532901 | 7:1,514,405 | G/A | — | pathogenic |
| rs373812497 | 7:1,514,416 | G/A | — | uncertain significance |
| rs367655126 | 7:1,514,427 | G/A | — | likely benign |
| rs201606213 | 7:1,514,437 | G/A | — | conflicting classifications of pathogenicity |
| rs780284734 | 7:1,514,455 | C/T | — | uncertain significance |
| rs368503457 | 7:1,514,456 | G/A | — | uncertain significance |
| rs193130310 | 7:1,515,602 | G/A | — | likely benign |
| rs751490375 | 7:1,515,616 | T/C | — | uncertain significance |
| rs2483305847 | 7:1,515,619 | G/A | — | uncertain significance |
| rs2483305864 | 7:1,515,624 | A/C | — | uncertain significance |
| rs115962286 | 7:1,515,634 | G/A | — | benign |
| rs372736624 | 7:1,515,637 | C/T | — | uncertain significance |
| rs1181195517 | 7:1,515,643 | C/A | — | uncertain significance |
| rs749007520 | 7:1,515,654 | G/A | — | uncertain significance |
| rs768259844 | 7:1,515,683 | G/C | — | uncertain significance |
| rs1337007462 | 7:1,515,687 | C/T | — | uncertain significance |
| rs563449443 | 7:1,515,694 | G/A | — | uncertain significance |
| rs183370246 | 7:1,515,698 | G/T | — | benign |
| rs773961874 | 7:1,515,706 | C/G | — | uncertain significance |
| rs754042710 | 7:1,515,714 | G/A | — | likely benign |
| rs1286686353 | 7:1,515,892 | G/T | — | pathogenic |
| rs374301655 | 7:1,515,918 | A/G | — | likely benign |
| rs200824374 | 7:1,515,926 | C/T | — | benign |
| rs1162752269 | 7:1,515,961 | C/T | — | uncertain significance |
| rs2483307214 | 7:1,515,977 | T/C | — | uncertain significance |
| rs375794790 | 7:1,515,984 | G/A | — | likely benign |
| rs777387810 | 7:1,515,996 | G/C | — | uncertain significance |
| rs1024693245 | 7:1,515,997 | T/C | — | uncertain significance |
| rs746167496 | 7:1,516,007 | G/A | — | uncertain significance |
| rs770264501 | 7:1,516,008 | C/T | — | likely benign |
| rs775566577 | 7:1,516,009 | G/A | — | uncertain significance |
| rs367724786 | 7:1,516,014 | C/T | — | likely benign |
| rs371534075 | 7:1,516,019 | C/T | — | uncertain significance |
| rs2483307529 | 7:1,516,048 | A/T | — | uncertain significance |
| rs1405790298 | 7:1,516,057 | C/T | — | uncertain significance |
| rs781663701 | 7:1,516,084 | C/T | — | uncertain significance |
| rs371637110 | 7:1,516,100 | G/T | — | benign |
Showing 100 of 424 variants. Use the SNP search for the full list.
Gene information from NCBI Gene. Variant classifications from ClinVar.