INTS6

integrator complex subunit 6

Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and is located in the critical region of loss of heterozygosity (LOH). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2015]

Known Variants38 total

rsidPosition (GRCh37)AllelesClassClinVar
rs956304313:51,908,316A/Cupstream gene variant
rs953564613:51,913,708C/Tupstream gene variant
rs96899778713:51,939,895C/Tuncertain significance
rs6174988413:51,941,943T/Cbenign
rs14992457513:51,941,976T/Clikely benign
rs195572325913:51,942,004T/Cuncertain significance
rs14498538913:51,942,005G/Auncertain significance
rs36933040013:51,943,129C/Guncertain significance
rs254160917613:51,943,141T/Guncertain significance
rs134652285113:51,943,161T/Cuncertain significance
rs145272520413:51,943,192T/Cuncertain significance
rs254160955613:51,943,224T/Guncertain significance
rs156620439013:51,943,302T/Cuncertain significance
rs14911592813:51,943,306T/Cbenign
rs74588135713:51,943,312G/Auncertain significance
rs19988611313:51,943,338G/Clikely benign
rs77271508913:51,943,350G/Auncertain significance
rs94070192713:51,943,434G/Cuncertain significance
rs135001525413:51,943,437G/Auncertain significance
rs119728946013:51,948,373T/Auncertain significance
rs36934883713:51,948,491T/Cuncertain significance
rs254162476413:51,948,851A/Guncertain significance
rs57770460213:51,950,265G/Auncertain significance
rs213789333813:51,950,306A/Tuncertain significance
rs14015632213:51,952,423G/Alikely benign
rs142993112213:51,952,494T/Cuncertain significance
rs13983293213:51,952,535T/Cuncertain significance
rs116781356513:51,952,583A/Cuncertain significance
rs75710263213:51,953,647T/Cuncertain significance
rs6174988513:51,956,225T/Gbenign
rs254165121413:51,957,503A/Cuncertain significance
rs254165220813:51,957,796T/Auncertain significance
rs13803020713:51,961,679A/Gbenign
rs254168225813:51,969,434A/Guncertain significance
rs20060369713:51,969,476T/Auncertain significance
rs75701777113:51,969,494C/Guncertain significance
rs78032346813:51,969,513A/Guncertain significance
rs14157361913:52,004,522A/Gbenign

Gene information from NCBI Gene. Variant classifications from ClinVar.