IQGAP1
IQ motif containing GTPase activating protein 1
Summary
This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines. [provided by RefSeq, Jul 2008]
Known Variants85 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs781475321 | 15:90,931,584 | C/T | — | uncertain significance |
| rs774795827 | 15:90,931,613 | C/T | — | uncertain significance |
| rs757668259 | 15:90,931,623 | A/G | — | uncertain significance |
| rs149599856 | 15:90,934,008 | G/A | — | uncertain significance |
| rs1384528019 | 15:90,934,056 | C/T | — | uncertain significance |
| rs757103088 | 15:90,934,065 | G/A | — | uncertain significance |
| rs7167704 | 15:90,956,801 | G/T | regulatory region variant | — |
| rs10459676 | 15:90,960,654 | A/G | intron variant | — |
| rs777290308 | 15:90,969,437 | T/A | — | uncertain significance |
| rs777591579 | 15:90,969,479 | G/A | — | uncertain significance |
| rs147018296 | 15:90,972,903 | C/T | — | benign |
| rs16944405 | 15:90,975,517 | A/T | — | — |
| rs540046631 | 15:90,976,975 | A/G | — | uncertain significance |
| rs745920816 | 15:90,983,751 | A/G | — | uncertain significance |
| rs1483044227 | 15:90,983,786 | G/A | — | uncertain significance |
| rs772573837 | 15:90,983,844 | G/A | — | uncertain significance |
| rs114889611 | 15:90,984,862 | C/T | — | benign |
| rs138352975 | 15:90,984,869 | A/G | — | benign |
| rs201193336 | 15:90,991,825 | A/G | — | likely benign |
| rs751054433 | 15:90,991,898 | G/A | — | uncertain significance |
| rs140946408 | 15:90,991,950 | T/G | — | uncertain significance |
| rs745825285 | 15:90,992,813 | A/G | — | uncertain significance |
| rs753055022 | 15:90,996,012 | G/A | — | uncertain significance |
| rs2505362311 | 15:90,996,028 | T/C | — | uncertain significance |
| rs777272899 | 15:90,996,085 | C/A | — | uncertain significance |
| rs756912806 | 15:90,996,157 | G/A | — | likely benign |
| rs2505363243 | 15:90,996,404 | T/C | — | uncertain significance |
| rs1250916445 | 15:90,996,433 | G/A | — | uncertain significance |
| rs1965630787 | 15:90,996,449 | A/G | — | uncertain significance |
| rs568017868 | 15:90,996,500 | A/G | — | uncertain significance |
| rs776644965 | 15:90,996,507 | G/C | — | uncertain significance |
| rs2505363531 | 15:90,996,512 | A/G | — | uncertain significance |
| rs752194177 | 15:90,997,687 | G/C | — | uncertain significance |
| rs1042073179 | 15:91,010,733 | A/G | — | uncertain significance |
| rs902140093 | 15:91,010,747 | G/C | — | uncertain significance |
| rs748481299 | 15:91,010,786 | G/T | — | uncertain significance |
| rs771049690 | 15:91,010,804 | C/T | — | uncertain significance |
| rs372432449 | 15:91,010,823 | A/T | — | uncertain significance |
| rs4031435 | 15:91,015,566 | G/C | intron variant | — |
| rs1965924173 | 15:91,016,082 | C/G | — | uncertain significance |
| rs997846298 | 15:91,016,091 | C/G | — | uncertain significance |
| rs1464156579 | 15:91,016,100 | A/G | — | uncertain significance |
| rs200740824 | 15:91,016,157 | G/C | — | uncertain significance |
| rs370030365 | 15:91,016,165 | G/A | — | uncertain significance |
| rs980602514 | 15:91,016,190 | G/T | — | uncertain significance |
| rs190515009 | 15:91,017,005 | G/A | — | uncertain significance |
| rs745636288 | 15:91,017,022 | G/C | — | uncertain significance |
| rs372386381 | 15:91,017,192 | G/A | — | uncertain significance |
| rs757987204 | 15:91,017,198 | A/G | — | uncertain significance |
| rs2505396880 | 15:91,017,735 | C/T | — | uncertain significance |
| rs142816966 | 15:91,017,812 | A/C | — | uncertain significance |
| rs199811461 | 15:91,019,891 | A/G | — | benign |
| rs778722659 | 15:91,019,923 | C/A | — | uncertain significance |
| rs745393741 | 15:91,020,009 | G/A | — | uncertain significance |
| rs371671746 | 15:91,020,449 | C/A | — | uncertain significance |
| rs10083661 | 15:91,022,339 | G/A | regulatory region variant | — |
| rs754002822 | 15:91,025,227 | T/G | — | uncertain significance |
| rs886039901 | 15:91,025,451 | A/G | — | uncertain significance |
| rs768991566 | 15:91,025,498 | G/T | — | uncertain significance |
| rs763321490 | 15:91,026,719 | A/G | — | uncertain significance |
| rs144407263 | 15:91,026,728 | A/G | — | uncertain significance |
| rs117246983 | 15:91,026,730 | G/A | — | likely benign |
| rs140035684 | 15:91,026,731 | C/T | — | uncertain significance |
| rs138269416 | 15:91,027,543 | G/A | — | benign |
| rs114361502 | 15:91,029,318 | A/G | — | benign |
| rs370762117 | 15:91,029,333 | C/T | — | likely benign |
| rs146984888 | 15:91,030,216 | A/G | — | uncertain significance |
| rs138905294 | 15:91,030,238 | G/A | — | likely benign |
| rs1596292195 | 15:91,030,753 | T/A | — | uncertain significance |
| rs1966143836 | 15:91,030,768 | G/C | — | uncertain significance |
| rs181523835 | 15:91,030,772 | G/T | — | uncertain significance |
| rs752418699 | 15:91,034,630 | G/A | — | uncertain significance |
| rs2505421621 | 15:91,034,646 | G/A | — | uncertain significance |
| rs141544591 | 15:91,034,662 | A/T | — | uncertain significance |
| rs2505421786 | 15:91,034,722 | T/C | — | uncertain significance |
| rs780533039 | 15:91,034,747 | A/C | — | uncertain significance |
| rs1267537055 | 15:91,034,758 | T/C | — | uncertain significance |
| rs146200248 | 15:91,034,776 | G/A | — | likely benign |
| rs7173724 | 15:91,036,855 | A/T | — | — |
| rs11636089 | 15:91,039,527 | C/T | intron variant | — |
| rs2505429068 | 15:91,040,466 | T/G | — | uncertain significance |
| rs2301832 | 15:91,040,725 | A/T | intron variant | — |
| rs1425163837 | 15:91,043,332 | G/A | — | uncertain significance |
| rs11609 | 15:91,043,765 | C/G | 3 prime UTR variant | — |
| rs1042538 | 15:91,044,408 | T/A | 3 prime UTR variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.