ITGAD

integrin subunit alpha D

Summary

This gene belongs to the beta-2 integrin family of membrane glycoproteins, which are are composed of non-covalently linked alpha and beta subunits to form a heterodimer. It encodes the alpha subunit of the cell surface heterodimers and is involved in the activation and adhesion functions of leukocytes. The gene is located about 11kb downstream of the integrin subunit alpha X gene, another member of the integrin family. It is expressed in the tissue and circulating myeloid leukocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Known Variants89 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs572954905	16:31,402,773	C/G	—	—
rs190014941	16:31,405,602	C/T	—	uncertain significance
rs750241467	16:31,405,639	C/A	—	uncertain significance
rs754577254	16:31,405,652	G/A	—	uncertain significance
rs2544636136	16:31,408,693	G/A	—	uncertain significance
rs758825960	16:31,408,696	C/A	—	uncertain significance
rs150049273	16:31,408,724	C/T	—	uncertain significance
rs763017246	16:31,408,730	G/A	—	uncertain significance
rs754064352	16:31,408,980	G/A	—	uncertain significance
rs776882400	16:31,409,166	G/C	—	uncertain significance
rs2544644576	16:31,409,173	T/G	—	uncertain significance
rs765383458	16:31,409,189	C/T	—	uncertain significance
rs777128944	16:31,409,221	G/A	—	uncertain significance
rs201296084	16:31,409,227	C/T	—	uncertain significance
rs2454908	16:31,411,185	C/G	—	—
rs1199557753	16:31,413,457	A/C	—	uncertain significance
rs142325489	16:31,413,537	A/G	—	uncertain significance
rs773083967	16:31,414,906	T/C	—	uncertain significance
rs144787223	16:31,414,948	C/T	—	uncertain significance
rs538730001	16:31,418,868	G/A	—	uncertain significance
rs369026223	16:31,418,892	T/C	—	uncertain significance
rs549133508	16:31,419,141	T/C	—	uncertain significance
rs149997824	16:31,419,151	C/T	—	uncertain significance
rs1178779144	16:31,419,162	G/A	—	uncertain significance
rs772600894	16:31,419,220	A/G	—	uncertain significance
rs143491528	16:31,419,809	C/A	—	uncertain significance
rs752524967	16:31,419,811	C/T	—	uncertain significance
rs778335533	16:31,421,731	G/A	—	uncertain significance
rs562967775	16:31,421,751	C/A	—	uncertain significance
rs143616456	16:31,421,803	A/C	—	uncertain significance
rs374346767	16:31,421,821	G/A	—	uncertain significance
rs2544736025	16:31,422,072	T/C	—	uncertain significance
rs759237625	16:31,422,097	C/G	—	uncertain significance
rs998068799	16:31,422,110	G/C	—	uncertain significance
rs140839965	16:31,422,116	C/T	—	uncertain significance
rs1241760427	16:31,422,132	G/T	—	uncertain significance
rs80152569	16:31,422,399	C/G	—	uncertain significance
rs753320103	16:31,422,457	G/A	—	uncertain significance
rs766254726	16:31,422,476	C/A	—	uncertain significance
rs202112357	16:31,422,534	G/T	—	uncertain significance
rs369256257	16:31,422,659	C/T	—	likely benign
rs143276012	16:31,422,665	G/A	—	uncertain significance
rs768096609	16:31,422,750	T/C	—	uncertain significance
rs201038541	16:31,422,759	C/T	—	uncertain significance
rs376432799	16:31,422,777	G/A	—	likely benign
rs565500189	16:31,422,804	C/T	—	uncertain significance
rs558081828	16:31,422,807	C/T	—	uncertain significance
rs537084686	16:31,422,810	A/G	—	likely benign
rs555043054	16:31,422,812	T/C	—	uncertain significance
rs141116692	16:31,422,815	G/A	—	likely benign
rs766626429	16:31,424,264	G/A	—	uncertain significance
rs1183367720	16:31,424,267	C/T	—	uncertain significance
rs143512956	16:31,424,522	G/A	—	uncertain significance
rs749852262	16:31,424,528	G/A	—	likely benign
rs571120150	16:31,424,550	G/T	—	uncertain significance
rs759191924	16:31,425,808	T/C	—	uncertain significance
rs139267444	16:31,426,268	C/T	—	uncertain significance
rs768316242	16:31,426,283	G/A	—	likely benign
rs1342168533	16:31,426,304	A/T	—	uncertain significance
rs773678366	16:31,427,843	T/C	—	uncertain significance
rs1054898296	16:31,427,942	C/T	—	uncertain significance
rs1436564494	16:31,429,412	G/T	—	uncertain significance
rs760726177	16:31,429,421	G/A	—	likely benign
rs369360258	16:31,429,472	G/A	—	uncertain significance
rs1046730444	16:31,429,640	T/C	—	uncertain significance
rs141738009	16:31,429,692	G/T	—	uncertain significance
rs2544794432	16:31,429,854	G/T	—	uncertain significance
rs148163652	16:31,429,858	A/C	—	uncertain significance
rs141976418	16:31,429,875	A/G	—	likely benign
rs764251641	16:31,434,445	T/A	—	uncertain significance
rs892238936	16:31,434,446	C/A	—	uncertain significance
rs2544812407	16:31,434,487	A/G	—	uncertain significance
rs193921125	16:31,434,490	A/C	—	uncertain significance
rs769407048	16:31,434,499	G/A	—	uncertain significance
rs777270472	16:31,434,506	G/A	—	uncertain significance
rs761068465	16:31,434,512	G/A	—	uncertain significance
rs140899350	16:31,434,738	C/T	—	likely benign
rs142645960	16:31,434,772	C/T	—	uncertain significance
rs199588079	16:31,434,895	C/T	—	uncertain significance
rs182797885	16:31,435,224	A/G	—	uncertain significance
rs535493782	16:31,435,275	G/A	—	uncertain significance
rs201938902	16:31,435,367	A/G	—	—
rs773824422	16:31,435,480	G/A	—	uncertain significance
rs192324582	16:31,435,523	A/G	—	uncertain significance
rs750369318	16:31,435,797	G/A	—	uncertain significance
rs368846196	16:31,437,336	C/G	—	uncertain significance
rs138245714	16:31,437,352	G/A	—	uncertain significance
rs749199872	16:31,437,397	C/T	—	uncertain significance
rs370863620	16:31,437,421	G/C	—	uncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.