IVL

involucrin

Summary

Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin. [provided by RefSeq, Jul 2008]

Known Variants69 total

rsidPosition (GRCh37)AllelesClassClinVar
rs2013034541:152,882,302C/T—uncertain significance
rs1454301761:152,882,359C/G—uncertain significance
rs9233236151:152,882,361C/A—uncertain significance
rs9108388191:152,882,423G/C—uncertain significance
rs8680674561:152,882,454G/A—uncertain significance
rs5722794541:152,882,648A/G—likely benign
rs7569493131:152,882,674T/A—uncertain significance
rs1423585621:152,882,760C/G—uncertain significance
rs1144484371:152,882,765G/A—benign
rs7564727191:152,882,767A/T—uncertain significance
rs112051351:152,882,786A/G—likely benign
rs5417362591:152,882,800C/T—uncertain significance
rs112051361:152,882,801G/A—likely benign
rs25265826951:152,882,802G/C—uncertain significance
rs751119741:152,882,811G/A—benign
rs2005164791:152,882,849G/T—uncertain significance
rs2009167861:152,882,860C/T—likely benign
rs13635156681:152,882,897G/T—uncertain significance
rs13341805451:152,882,906G/A—likely benign
rs12544069821:152,882,928C/G—uncertain significance
rs75207111:152,882,982C/G—benign
rs16499313791:152,883,000C/G—uncertain significance
rs9985111541:152,883,003G/C—uncertain significance
rs44590541:152,883,036C/T—benign
rs7802526581:152,883,087C/A—uncertain significance
rs14465519631:152,883,129C/A—uncertain significance
rs1806867711:152,883,137G/A—benign
rs3748188071:152,883,141G/A—uncertain significance
rs1843890681:152,883,155G/T—likely benign
rs15709147561:152,883,206G/A—likely benign
rs10006918681:152,883,224G/T—uncertain significance
rs3707906051:152,883,230G/A—likely benign
rs7551085001:152,883,240C/T—uncertain significance
rs5571527441:152,883,241C/G—uncertain significance
rs14295984841:152,883,264G/A—uncertain significance
rs12089774331:152,883,299G/C—uncertain significance
rs1823258851:152,883,317G/T—likely benign
rs3676338321:152,883,348C/G—uncertain significance
rs2019969631:152,883,381G/T—uncertain significance
rs9045422331:152,883,421C/T—likely benign
rs5596170801:152,883,438G/A—uncertain significance
rs13964109191:152,883,445G/A—uncertain significance
rs10536426941:152,883,447C/A—uncertain significance
rs13176410601:152,883,459C/G—uncertain significance
rs12516325951:152,883,482G/A—likely benign
rs3684321511:152,883,487A/G—uncertain significance
rs10017587451:152,883,502A/T—uncertain significance
rs13742693931:152,883,516C/T—likely benign
rs16499703391:152,883,522G/A—uncertain significance
rs14543194591:152,883,555G/A—uncertain significance
rs1397032211:152,883,573G/A—uncertain significance
rs7736009471:152,883,579C/G—uncertain significance
rs617313401:152,883,620G/A—benign
rs1163736381:152,883,621T/A—benign
rs7545789931:152,883,626G/T—uncertain significance
rs1469724841:152,883,647G/A—benign
rs1853490361:152,883,681C/G—uncertain significance
rs1463319891:152,883,687C/T—uncertain significance
rs7619149931:152,883,772C/G—uncertain significance
rs1497188231:152,883,786C/G—benign
rs1412669531:152,883,789C/G—likely benign
rs7474204891:152,883,810C/G—uncertain significance
rs1386189911:152,883,825G/A—uncertain significance
rs10477390201:152,883,843G/A—uncertain significance
rs25265886161:152,883,943C/A—uncertain significance
rs3721091431:152,883,950G/A—likely benign
rs1456596861:152,883,983G/T—uncertain significance
rs7685580091:152,883,987C/G—uncertain significance
rs3682442181:152,884,023C/T—uncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.