KAZN

kazrin, periplakin interacting protein

Summary

This gene encodes a protein that plays a role in desmosome assembly, cell adhesion, cytoskeletal organization, and epidermal differentiation. This protein co-localizes with desmoplakin and the cytolinker protein periplakin. In general, this protein localizes to the nucleus, desmosomes, cell membrane, and cortical actin-based structures. Some isoforms of this protein also associate with microtubules. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity has not been verified. [provided by RefSeq, Aug 2011]

Known Variants38 total

rsidPosition (GRCh37)AllelesClassClinVar
rs1852185631:14,369,797T/Cintergenic variant
rs1871639481:14,399,146G/Aintergenic variant
rs24800541:14,792,535A/T
rs1814117221:14,793,829A/Tintergenic variant
rs7604667871:14,925,543A/Guncertain significance
rs7790035041:14,925,597G/Cuncertain significance
rs7759631111:14,925,632G/Cuncertain significance
rs7537977221:14,925,711G/Cuncertain significance
rs1127160541:14,933,910C/A
rs7469647951:15,287,180T/Guncertain significance
rs1469401931:15,287,288C/Auncertain significance
rs64297031:15,339,960T/Cintron variant
rs66672201:15,347,640G/Aregulatory region variant
rs7521914531:15,361,287A/Tuncertain significance
rs14216216261:15,361,331C/Tuncertain significance
rs2004964211:15,370,558G/Auncertain significance
rs7596709491:15,382,755C/Guncertain significance
rs7654515211:15,382,765C/Auncertain significance
rs2004380961:15,386,777C/Auncertain significance
rs9181115341:15,386,790C/Tuncertain significance
rs5388406241:15,390,080G/Auncertain significance
rs7512530601:15,420,745G/Auncertain significance
rs25218626421:15,420,756G/Auncertain significance
rs14760678681:15,420,798G/Auncertain significance
rs7474029381:15,421,375G/Auncertain significance
rs7799605551:15,428,196G/Auncertain significance
rs3679723331:15,428,238G/Auncertain significance
rs8962398581:15,429,903G/Auncertain significance
rs12354002271:15,430,532A/Guncertain significance
rs7811519821:15,430,538C/Tuncertain significance
rs7576199131:15,430,549G/Auncertain significance
rs1430837921:15,439,014G/Auncertain significance
rs7703167981:15,439,035C/Tuncertain significance
rs7793456041:15,441,015T/Auncertain significance
rs7733757991:15,441,041A/Tuncertain significance
rs3750461091:15,441,044C/Guncertain significance
rs5361734361:15,441,067C/Auncertain significance
rs7627093041:15,441,126G/Auncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.