KCNC4
potassium voltage-gated channel subfamily C member 4
Summary
The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. It generates atypical voltage-dependent transient current that may be important for neuronal excitability. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]
Known Variants49 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1356525916 | 1:110,754,255 | C/T | — | uncertain significance |
| rs535148746 | 1:110,754,326 | G/T | — | uncertain significance |
| rs2524689795 | 1:110,754,347 | A/T | — | likely benign |
| rs2524690011 | 1:110,754,363 | T/C | — | likely benign |
| rs2524690954 | 1:110,754,423 | G/A | — | uncertain significance |
| rs767520363 | 1:110,754,617 | G/C | — | uncertain significance |
| rs2524692773 | 1:110,754,626 | A/G | — | likely benign |
| rs369933360 | 1:110,754,628 | C/G | — | uncertain significance |
| rs1657490150 | 1:110,754,630 | G/C | — | uncertain significance |
| rs987916927 | 1:110,754,641 | A/G | — | likely benign |
| rs780944297 | 1:110,754,650 | G/A | — | uncertain significance |
| rs371290024 | 1:110,754,688 | G/C | — | likely benign |
| rs543075239 | 1:110,754,698 | G/C | — | uncertain significance |
| rs2524693810 | 1:110,754,707 | G/C | — | uncertain significance |
| rs758120447 | 1:110,754,720 | C/T | — | uncertain significance |
| rs764150342 | 1:110,754,726 | C/T | — | uncertain significance |
| rs966893561 | 1:110,765,667 | G/A | — | uncertain significance |
| rs376748217 | 1:110,765,674 | A/G | — | uncertain significance |
| rs141629939 | 1:110,765,693 | C/T | — | likely benign |
| rs774629438 | 1:110,765,703 | A/G | — | uncertain significance |
| rs144762287 | 1:110,765,712 | G/A | — | uncertain significance |
| rs763803707 | 1:110,765,920 | C/G | — | uncertain significance |
| rs779859089 | 1:110,766,132 | C/G | — | uncertain significance |
| rs768187654 | 1:110,766,145 | G/A | — | uncertain significance |
| rs367870522 | 1:110,766,333 | G/A | — | uncertain significance |
| rs985277923 | 1:110,766,354 | A/G | — | uncertain significance |
| rs143546722 | 1:110,766,381 | C/T | — | uncertain significance |
| rs201533610 | 1:110,766,396 | C/T | — | uncertain significance |
| rs376704379 | 1:110,766,400 | G/A | — | uncertain significance |
| rs768599105 | 1:110,766,430 | G/A | — | uncertain significance |
| rs1169019795 | 1:110,766,487 | C/T | — | uncertain significance |
| rs143611044 | 1:110,766,490 | G/A | — | uncertain significance |
| rs770979171 | 1:110,766,506 | C/G | — | uncertain significance |
| rs373322407 | 1:110,766,519 | G/A | — | uncertain significance |
| rs149951194 | 1:110,768,602 | A/G | — | uncertain significance |
| rs142302926 | 1:110,768,686 | G/A | — | uncertain significance |
| rs137885705 | 1:110,768,695 | C/T | — | uncertain significance |
| rs2524763128 | 1:110,768,702 | T/C | — | uncertain significance |
| rs150481020 | 1:110,768,708 | G/A | — | uncertain significance |
| rs34480599 | 1:110,768,715 | C/A | — | likely benign |
| rs1033122106 | 1:110,768,726 | G/A | — | uncertain significance |
| rs773560393 | 1:110,768,767 | G/A | — | uncertain significance |
| rs777571978 | 1:110,768,779 | G/A | — | uncertain significance |
| rs200184574 | 1:110,768,794 | C/T | — | uncertain significance |
| rs958798 | 1:110,770,223 | G/A | — | — |
| rs761948155 | 1:110,774,881 | C/T | — | uncertain significance |
| rs772338469 | 1:110,774,884 | G/C | — | uncertain significance |
| rs143394794 | 1:110,780,247 | A/C | downstream gene variant | — |
| rs185491604 | 1:110,790,909 | G/A | intron variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.