KCNK10

potassium two pore domain channel subfamily K member 10

Summary

The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]

Known Variants36 total

rsidPosition (GRCh37)AllelesClassClinVar
rs75606558814:88,651,920G/Auncertain significance
rs14108052014:88,651,981C/Tlikely benign
rs20053582014:88,652,013T/Cuncertain significance
rs129901425114:88,652,039T/Guncertain significance
rs97599260514:88,652,049C/Tuncertain significance
rs78160062814:88,652,066C/Tuncertain significance
rs14149909914:88,652,067G/Auncertain significance
rs104184126914:88,652,072G/Auncertain significance
rs78057877414:88,652,161G/Alikely benign
rs77548028514:88,652,196G/Auncertain significance
rs20036652814:88,652,277G/Auncertain significance
rs76128102914:88,652,280C/Tuncertain significance
rs75995158814:88,652,364G/Auncertain significance
rs14533857814:88,652,378C/Tuncertain significance
rs75745836214:88,652,379G/Auncertain significance
rs77191765614:88,652,394G/Auncertain significance
rs76013618314:88,652,404A/Tuncertain significance
rs37178573614:88,652,462G/Auncertain significance
rs250374576214:88,654,323C/Alikely benign
rs52913916014:88,654,425C/Guncertain significance
rs74584656014:88,654,445C/Auncertain significance
rs36927696814:88,693,749T/Auncertain significance
rs136071314714:88,693,844T/Cuncertain significance
rs188716151614:88,729,571G/Auncertain significance
rs75156283714:88,729,593G/Auncertain significance
rs76756639814:88,729,604G/Auncertain significance
rs250391141714:88,729,655A/Guncertain significance
rs76666166614:88,729,662G/Auncertain significance
rs123294380314:88,729,716C/Guncertain significance
rs15077914014:88,729,808C/Tuncertain significance
rs13837955314:88,729,809G/Auncertain significance
rs37173255714:88,729,829G/Auncertain significance
rs77001878114:88,729,856C/Tuncertain significance
rs97583146314:88,729,884C/Tuncertain significance
rs19228521514:88,762,143T/Cintron variant
rs19144905914:88,793,532A/Cupstream gene variant

Gene information from NCBI Gene. Variant classifications from ClinVar.