KCNK10
potassium two pore domain channel subfamily K member 10
Summary
The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]
Known Variants36 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs756065588 | 14:88,651,920 | G/A | — | uncertain significance |
| rs141080520 | 14:88,651,981 | C/T | — | likely benign |
| rs200535820 | 14:88,652,013 | T/C | — | uncertain significance |
| rs1299014251 | 14:88,652,039 | T/G | — | uncertain significance |
| rs975992605 | 14:88,652,049 | C/T | — | uncertain significance |
| rs781600628 | 14:88,652,066 | C/T | — | uncertain significance |
| rs141499099 | 14:88,652,067 | G/A | — | uncertain significance |
| rs1041841269 | 14:88,652,072 | G/A | — | uncertain significance |
| rs780578774 | 14:88,652,161 | G/A | — | likely benign |
| rs775480285 | 14:88,652,196 | G/A | — | uncertain significance |
| rs200366528 | 14:88,652,277 | G/A | — | uncertain significance |
| rs761281029 | 14:88,652,280 | C/T | — | uncertain significance |
| rs759951588 | 14:88,652,364 | G/A | — | uncertain significance |
| rs145338578 | 14:88,652,378 | C/T | — | uncertain significance |
| rs757458362 | 14:88,652,379 | G/A | — | uncertain significance |
| rs771917656 | 14:88,652,394 | G/A | — | uncertain significance |
| rs760136183 | 14:88,652,404 | A/T | — | uncertain significance |
| rs371785736 | 14:88,652,462 | G/A | — | uncertain significance |
| rs2503745762 | 14:88,654,323 | C/A | — | likely benign |
| rs529139160 | 14:88,654,425 | C/G | — | uncertain significance |
| rs745846560 | 14:88,654,445 | C/A | — | uncertain significance |
| rs369276968 | 14:88,693,749 | T/A | — | uncertain significance |
| rs1360713147 | 14:88,693,844 | T/C | — | uncertain significance |
| rs1887161516 | 14:88,729,571 | G/A | — | uncertain significance |
| rs751562837 | 14:88,729,593 | G/A | — | uncertain significance |
| rs767566398 | 14:88,729,604 | G/A | — | uncertain significance |
| rs2503911417 | 14:88,729,655 | A/G | — | uncertain significance |
| rs766661666 | 14:88,729,662 | G/A | — | uncertain significance |
| rs1232943803 | 14:88,729,716 | C/G | — | uncertain significance |
| rs150779140 | 14:88,729,808 | C/T | — | uncertain significance |
| rs138379553 | 14:88,729,809 | G/A | — | uncertain significance |
| rs371732557 | 14:88,729,829 | G/A | — | uncertain significance |
| rs770018781 | 14:88,729,856 | C/T | — | uncertain significance |
| rs975831463 | 14:88,729,884 | C/T | — | uncertain significance |
| rs192285215 | 14:88,762,143 | T/C | intron variant | — |
| rs191449059 | 14:88,793,532 | A/C | upstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.