KISS1
KiSS-1 metastasis suppressor
Summary
This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH neurons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues. [provided by RefSeq, Jun 2022]
Known Variants43 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs76834242 | 1:204,159,359 | T/C | — | benign |
| rs540653478 | 1:204,159,539 | C/G | — | benign |
| rs1132506 | 1:204,159,542 | G/C | — | benign |
| rs928092702 | 1:204,159,654 | C/T | — | likely benign |
| rs1455684230 | 1:204,159,662 | T/C | — | uncertain significance |
| rs199666322 | 1:204,159,680 | A/G | — | uncertain significance |
| rs1303540530 | 1:204,159,689 | A/T | — | uncertain significance |
| rs587777835 | 1:204,159,690 | G/C | missense variant | pathogenic |
| rs752674239 | 1:204,159,699 | C/T | — | likely benign |
| rs192636495 | 1:204,159,701 | G/T | missense variant | benign |
| rs2527538182 | 1:204,159,736 | T/A | — | uncertain significance |
| rs184298230 | 1:204,159,744 | G/A | — | benign |
| rs777274044 | 1:204,159,746 | G/A | — | uncertain significance |
| rs201073751 | 1:204,159,761 | G/A | — | uncertain significance |
| rs762880182 | 1:204,159,762 | G/T | — | likely benign |
| rs760697034 | 1:204,159,766 | G/C | — | uncertain significance |
| rs754159096 | 1:204,159,775 | C/T | — | uncertain significance |
| rs4889 | 1:204,159,787 | G/C | missense variant | benign |
| rs998730842 | 1:204,159,789 | G/A | — | likely benign |
| rs745585227 | 1:204,159,799 | C/T | — | uncertain significance |
| rs587777843 | 1:204,159,809 | G/A | — | uncertain significance |
| rs1377786663 | 1:204,159,830 | G/A | — | uncertain significance |
| rs752056340 | 1:204,159,832 | C/T | — | uncertain significance |
| rs774329614 | 1:204,159,873 | C/T | — | likely benign |
| rs1194935052 | 1:204,159,874 | G/A | — | uncertain significance |
| rs928040235 | 1:204,159,887 | C/G | — | uncertain significance |
| rs1132112 | 1:204,159,891 | G/A | — | likely benign |
| rs931590237 | 1:204,159,895 | G/A | — | uncertain significance |
| rs368273357 | 1:204,159,897 | C/T | — | likely benign |
| rs35431622 | 1:204,159,922 | C/T | — | benign |
| rs35737316 | 1:204,161,534 | C/T | — | — |
| rs532969667 | 1:204,161,902 | C/T | — | uncertain significance |
| rs748737279 | 1:204,161,929 | C/T | — | uncertain significance |
| rs12998 | 1:204,161,947 | C/T | missense variant | benign |
| rs753395436 | 1:204,161,956 | G/T | — | uncertain significance |
| rs10158616 | 1:204,162,142 | G/T | — | benign |
| rs12097666 | 1:204,162,212 | T/C | — | benign |
| rs4951319 | 1:204,162,230 | T/C | — | benign |
| rs139684727 | 1:204,165,538 | G/A | — | likely benign |
| rs3924587 | 1:204,165,554 | C/T | — | benign |
| rs770004886 | 1:204,165,663 | G/A | — | likely benign |
| rs72749747 | 1:204,165,688 | C/T | — | likely benign |
| rs56095702 | 1:204,165,981 | A/G | — | benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.