KLHL21
kelch like family member 21
Summary
Enables cullin family protein binding activity. Contributes to ubiquitin-protein transferase activity. Involved in chromosome passenger complex localization to spindle midzone; protein ubiquitination; and regulation of cytokinesis. Located in polar microtubule. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants50 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs141252990 | 1:6,653,440 | G/A | — | benign |
| rs757545813 | 1:6,653,448 | G/A | — | uncertain significance |
| rs750408643 | 1:6,653,450 | G/A | — | likely benign |
| rs143513148 | 1:6,653,456 | C/T | — | uncertain significance |
| rs772447646 | 1:6,653,507 | C/T | — | uncertain significance |
| rs779454065 | 1:6,653,519 | A/G | — | uncertain significance |
| rs748454656 | 1:6,653,520 | A/T | — | uncertain significance |
| rs556440546 | 1:6,653,597 | C/A | — | uncertain significance |
| rs560480904 | 1:6,653,639 | G/A | — | uncertain significance |
| rs562159346 | 1:6,653,687 | C/A | — | uncertain significance |
| rs1421059980 | 1:6,659,150 | C/T | — | uncertain significance |
| rs200103163 | 1:6,659,236 | T/C | — | uncertain significance |
| rs143141370 | 1:6,659,292 | G/A | — | likely benign |
| rs2522093525 | 1:6,659,302 | G/A | — | uncertain significance |
| rs1325418322 | 1:6,659,344 | T/C | — | uncertain significance |
| rs1420202412 | 1:6,659,351 | A/T | — | uncertain significance |
| rs538024704 | 1:6,659,366 | C/T | — | uncertain significance |
| rs1442208343 | 1:6,659,378 | C/T | — | uncertain significance |
| rs139415576 | 1:6,659,437 | G/A | — | likely benign |
| rs143989562 | 1:6,659,460 | G/C | — | uncertain significance |
| rs761423081 | 1:6,659,480 | C/T | — | uncertain significance |
| rs376471142 | 1:6,659,488 | T/A | — | uncertain significance |
| rs369651794 | 1:6,659,498 | A/T | — | uncertain significance |
| rs556529079 | 1:6,659,571 | C/T | — | — |
| rs2232456 | 1:6,661,981 | G/A | — | benign |
| rs1316992370 | 1:6,662,033 | G/A | — | uncertain significance |
| rs2522110901 | 1:6,662,141 | C/T | — | uncertain significance |
| rs779185399 | 1:6,662,145 | C/A | — | uncertain significance |
| rs2522111811 | 1:6,662,205 | G/A | — | uncertain significance |
| rs1297201921 | 1:6,662,223 | G/T | — | uncertain significance |
| rs2522111948 | 1:6,662,225 | G/A | — | uncertain significance |
| rs1641033957 | 1:6,662,232 | G/C | — | uncertain significance |
| rs2522112386 | 1:6,662,258 | C/A | — | uncertain significance |
| rs369534954 | 1:6,662,288 | G/A | — | benign |
| rs1268763835 | 1:6,662,316 | C/T | — | uncertain significance |
| rs887843061 | 1:6,662,321 | C/T | — | uncertain significance |
| rs760669785 | 1:6,662,325 | G/T | — | uncertain significance |
| rs1292721663 | 1:6,662,377 | C/G | — | uncertain significance |
| rs1353661587 | 1:6,662,427 | A/C | — | likely benign |
| rs372833088 | 1:6,662,431 | G/T | — | uncertain significance |
| rs775154413 | 1:6,662,515 | C/T | — | likely benign |
| rs1393558207 | 1:6,662,520 | C/G | — | uncertain significance |
| rs773318283 | 1:6,662,645 | C/A | — | uncertain significance |
| rs1641050057 | 1:6,662,657 | G/A | — | uncertain significance |
| rs575418153 | 1:6,662,755 | C/T | — | likely benign |
| rs771732674 | 1:6,662,784 | G/A | — | uncertain significance |
| rs1039618349 | 1:6,662,792 | C/A | — | uncertain significance |
| rs751245875 | 1:6,662,796 | G/A | — | likely benign |
| rs754815383 | 1:6,662,797 | C/T | — | likely benign |
| rs1040833812 | 1:6,662,858 | A/G | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.