KLHL42
kelch like family member 42
Summary
Contributes to ubiquitin-protein transferase activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process; protein polyubiquitination; and regulation of microtubule-based process. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants15 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs11049144 | 12:27,931,511 | C/A | regulatory region variant | — |
| rs985719060 | 12:27,933,303 | C/G | — | uncertain significance |
| rs772154475 | 12:27,933,403 | G/A | — | uncertain significance |
| rs968487719 | 12:27,933,672 | G/T | — | uncertain significance |
| rs753195539 | 12:27,933,684 | G/T | — | uncertain significance |
| rs757348968 | 12:27,933,787 | C/T | — | uncertain significance |
| rs139400429 | 12:27,933,851 | C/T | synonymous variant | — |
| rs2539886523 | 12:27,933,852 | G/T | — | uncertain significance |
| rs201456188 | 12:27,934,026 | C/G | — | uncertain significance |
| rs757102815 | 12:27,934,075 | C/T | — | uncertain significance |
| rs1271765809 | 12:27,937,287 | C/G | — | — |
| rs150101023 | 12:27,944,733 | A/G | — | uncertain significance |
| rs774561489 | 12:27,944,754 | C/A | — | uncertain significance |
| rs766218670 | 12:27,944,763 | A/C | — | uncertain significance |
| rs143659975 | 12:27,945,526 | G/A | intron variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.