KLK10
kallikrein related peptidase 10
Summary
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Known Variants26 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs150445404 | 19:51,518,115 | C/G | — | uncertain significance |
| rs746747251 | 19:51,518,174 | G/A | — | uncertain significance |
| rs760098715 | 19:51,518,195 | C/T | — | uncertain significance |
| rs772335801 | 19:51,518,196 | C/T | — | uncertain significance |
| rs142960865 | 19:51,518,692 | C/T | — | likely benign |
| rs371603716 | 19:51,518,714 | T/C | — | uncertain significance |
| rs139925315 | 19:51,518,759 | G/A | — | uncertain significance |
| rs772069381 | 19:51,519,143 | C/T | — | uncertain significance |
| rs775528267 | 19:51,519,144 | G/A | — | uncertain significance |
| rs2514223627 | 19:51,519,155 | G/A | — | uncertain significance |
| rs1219739860 | 19:51,519,165 | C/T | — | uncertain significance |
| rs755252868 | 19:51,519,185 | C/T | — | uncertain significance |
| rs767124161 | 19:51,519,186 | C/T | — | uncertain significance |
| rs201291525 | 19:51,519,200 | C/T | — | likely benign |
| rs2075690 | 19:51,519,236 | A/G | missense variant | — |
| rs1481872020 | 19:51,519,240 | C/T | — | uncertain significance |
| rs149739565 | 19:51,519,243 | C/G | — | uncertain significance |
| rs769158285 | 19:51,519,282 | C/T | — | uncertain significance |
| rs146426256 | 19:51,519,341 | C/T | — | uncertain significance |
| rs554122041 | 19:51,520,138 | G/A | — | — |
| rs746655149 | 19:51,520,498 | T/C | — | uncertain significance |
| rs7255834 | 19:51,521,876 | T/C | downstream gene variant | — |
| rs767114874 | 19:51,522,322 | G/A | — | uncertain significance |
| rs372382475 | 19:51,522,340 | G/T | — | uncertain significance |
| rs10425377 | 19:51,523,002 | G/C | regulatory region variant | — |
| rs3760738 | 19:51,523,897 | A/G | upstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.