KRT19

keratin 19

Summary

The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]

Known Variants36 total

rsidPosition (GRCh37)AllelesClassClinVar
rs14124126017:39,680,011G/Tuncertain significance
rs13935035917:39,680,084G/Auncertain significance
rs57198536617:39,680,086G/Auncertain significance
rs54054190217:39,680,126G/Auncertain significance
rs75871403717:39,680,140C/Tuncertain significance
rs92270939517:39,680,168C/Tlikely benign
rs14414911317:39,680,191G/Tuncertain significance
rs37653466817:39,680,397T/Cuncertain significance
rs37276517717:39,680,442G/Auncertain significance
rs250868281017:39,680,471A/Guncertain significance
rs77148122917:39,680,662C/Tuncertain significance
rs250868335217:39,680,719A/Guncertain significance
rs26760765417:39,680,768C/Tnot provided
rs11767158517:39,681,195C/Tuncertain significance
rs26760765517:39,681,203G/Anot provided
rs77102504817:39,681,220C/Tuncertain significance
rs75837051717:39,681,470C/Guncertain significance
rs74598082017:39,681,471G/Auncertain significance
rs460117:39,681,475A/Gnot provided
rs14274760817:39,681,481G/Abenign
rs55177239917:39,682,487A/G
rs74830796817:39,684,114T/Guncertain significance
rs76251667317:39,684,169T/Guncertain significance
rs14556988517:39,684,269C/Abenign
rs74877898217:39,684,279C/Auncertain significance
rs76832871417:39,684,280C/Auncertain significance
rs143435154517:39,684,307A/Tuncertain significance
rs460217:39,684,321G/Cnot provided
rs250868895717:39,684,343C/Auncertain significance
rs89792129517:39,684,372C/Tuncertain significance
rs20046546517:39,684,402G/Tuncertain significance
rs1155088317:39,684,410G/Abenign
rs77074080317:39,684,425A/Cuncertain significance
rs20077703417:39,684,451C/Tnot provided
rs37383570317:39,684,481G/Tuncertain significance
rs5605197217:39,684,598C/Gnot provided

Gene information from NCBI Gene. Variant classifications from ClinVar.