KYAT1
kynurenine aminotransferase 1
Summary
This gene encodes a cytosolic enzyme that is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism can form reactive metabolites leading to nephrotoxicity and neurotoxicity. Increased levels of this enzyme have been linked to schizophrenia. Multiple transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Known Variants18 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs76253609 | 9:131,595,522 | G/T | upstream gene variant | — |
| rs374080396 | 9:131,596,048 | C/T | — | uncertain significance |
| rs75692348 | 9:131,596,074 | T/A | — | uncertain significance |
| rs181155432 | 9:131,596,090 | G/A | — | uncertain significance |
| rs146402491 | 9:131,597,679 | T/C | — | uncertain significance |
| rs770205049 | 9:131,597,853 | G/A | — | uncertain significance |
| rs2805102 | 9:131,598,767 | A/G | intron variant | — |
| rs761474860 | 9:131,599,980 | T/C | — | uncertain significance |
| rs559210769 | 9:131,600,016 | G/C | — | uncertain significance |
| rs572629163 | 9:131,600,026 | C/T | — | likely benign |
| rs2280841 | 9:131,600,111 | T/G | — | — |
| rs201161036 | 9:131,600,410 | T/C | missense variant | — |
| rs1831515367 | 9:131,600,606 | C/G | — | uncertain significance |
| rs1615 | 9:131,607,259 | G/A | regulatory region variant | — |
| rs2259043 | 9:131,607,921 | A/T | — | — |
| rs138949483 | 9:131,609,731 | G/A | — | benign |
| rs1029625062 | 9:131,627,454 | T/C | — | — |
| rs941960 | 9:131,641,032 | C/G | regulatory region variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.